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Identification of a naturally occurring peroxidase-lipoxygenase fusion protein.

Koljak R., Boutaud O., Shieh B.-H., Samel N., Brash A.R.

Science 277: 1994-1996 (1997)

Abstract:

A distant relative of catalase that is specialized for metabolism of a fatty acid hydroperoxide was identified. This heme peroxidase occurs in coral as part of a fusion protein, the other component of which is a lipoxygenase that forms the hydroperoxide substrate. The end product is an unstable epoxide (an allene oxide) that is a potential precursor of prostaglandin-like molecules. These results extend the known chemistry of catalase-like proteins and reveal a distinct type of enzymatic construct involved in the metabolism of polyunsaturated fatty acids.

LOX-DB entries related to this article: ph-aos-8r-lox