LOX-DB - Literature
Do 15-lipoxygenases have a common biological role?
Schewe T., Kuhn H.
Trends Biochem. Sci. 16: 369-373 (1991)Abstract:
In contrast to the well-studied role of 5-lipoxygenase in the arachidonic acid cascade that occurs in inflammatory cells, the biological role of the related 15-lipoxygenases in the metabolism of free polyenoic fatty acids is far from clear. However, the activity of 15-lipoxygenases with more complex substrates may play a crucial role in the differentiation and maturation of certain cell types and in the oxidative modification of lipoproteins in the early stages of atherosclerosis.