oc-12-lox
Gene name: ALOX12Species: rabbit (oryctolagus cuniculus)
Position of Oxygenation: 12
Substrate: arachidonic acid
Stereospecifity: S
Swissprot Entry: O19043
GenBank Entry: Z97654
Modeled 3D-Structure: file in pdb format (use Rasmol for viewing)
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Sequence: (662 Residues, 75.1 kDa)
GVYRVCVSTG ASIYAGSKNK VELWLVGQHG EVELGSCLRP SRNKEEEFKV NVSKYLGSLL FVKLRKKHFL KEDAWFCNWI SVQALGAAED KYWFPCYRWV VGDGVQSLPV GTGCTTVGDP QGLFQKHREQ ELEERRKLYQ WGSWKEGLIL NVAGSKLTDL PVDERFLEDK KIDFEASLAW GLAELALKNS LNILAPWKTL DDFNRIFWCG RSKLARRVRD SWQEDSLFGY QFLNGANPML LRRSVQLPAR LVFPPGMEEL QAQLEKELKA GTLFEADFAL LDNIKANVIL YCQQYLAAPL VMLKLQPDGK LMPMVIQLHL PKIGSSPPPL FLPTDPPMVW LLAKCWVRSS DLQVHELNSH LLRGHLMAEV FTVATMRCLP SIHPVFKLIV PHLRYTLEIN VRARNGLVSD FGIFDQIMST GGGGHVQLLQ QAGAFLTYRS FCPPDDLADR GLLGVESSFY AQDALRLWEI ISRYVQGIMG LYYKTDEAVR DDLELQSWCR EITEIGLQGA QKQGFPTSLQ SVAQACHFVT MCIFTCTGQH SSIHLGQLDW FTWVPNAPCT MRLPPPTTKD ATLETVMATL PNLHQSSLQM SIVWQLGRDQ PIMVPLGQHQ EEYFSGPEPR AVLEKFREEL AIMDKEIEVR NEKLDIPYEY LRPSIVENSV AI
Literature:
- Berger M., Schwarz K., Thiele H., Reimann I., Huth A., Borngraber S., Kuhn H., Thiele B.J.
"Simultaneous expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits."
J. Mol. Biol. 278: 935-948 (1998)
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