m-l12-lox
Gene name: ALOX12L or ALOX15Species: mouse (mus musculus)
Position of Oxygenation: 12 / 15
Substrate: arachidonic acid
Stereospecifity: S
Tissue: leucocyte
Swissprot Entry: P39654
GenBank Entry: U04331
Modeled 3D-Structure: file in pdb format (use Rasmol for viewing)
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Sequence: (662 Residues, 75.3 kDa)
GVYRIRVSTG DSVYAGSNNE VYLWLIGQHG EASLGKLFRP CRNSEAEFKV DVSEYLGPLL FVRVQKWHYL KEDAWFCNWI SVKGPGDQGS EYTFPCYRWV QGTSILNLPE GTGCTVVEDS QGLFRNHREE ELEERRSLYR WGNWKDGTIL NVAATSISDL PVDQRFREDK RLEFEASQVL GTMDTVINFP KNTVTCWKSL DDFNYVFKSG HTKMAERVRN SWKEDAFFGY QFLNGANPMV LKRSTCLPAR LVFPPGMEKL QAQLDEELKK GTLFEADFFL LDGIKANVIL CSQQYLAAPL VMLKLQPDGQ LLPIAIQLEL PKTGSTPPPI FTPLDPPMDW LLAKCWVRSS DLQLHELQAH LLRGHLVAEV FAVATMRCLP SVHPVFKLLV PHLLYTMEIN VRARSDLISE RGFFDKVMST GGGGHLDLLK QAGAFLTYSS LCPPDDLAER GLLDIDTCFY AKDALQLWQV MNRYVVGMFD LYYKTDQAVQ DDYELQSWCQ EITEIGLQGA QDRGFPTSLQ SRAQACHFIT MCIFTCTAQH SSIHLGQLDW FYWVPNAPCT MRLPPPKTKD ATMEKLMATL PNPNQSTLQI NVVWLLGRRQ AVMVPLGQHS EEHFPNPEAK AVLKKFREEL AALDKEIEIR NKSLDIPYEY LRPSLVENSV AI
Literature:
- Chen X.-S., Kurre U., Jenkins N.A., Copeland N.G., Funk C.D.
"cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases."
J. Biol. Chem. 269: 13979-13987 (1994)
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- Freire-Moar J., Alavi-Nassab A., Ng M., Mulkins M., Sigal E.
"Cloning and characterization of a murine macrophage lipoxygenase."
Biochim. Biophys. Acta 1254: 112-116 (1995)
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- Buerger F., Krieg P., Marks F., Fuerstenberger G.
"Positional- and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymes."
Biochem. J. 348: 329-335 (2000)
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