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m-12r-lox

Gene name: ALOX12B or ALOXE2

Species: mouse (mus musculus)

Position of Oxygenation: 12

Substrate: arachidonyl ester

Stereospecifity: R

Tissue: epidermis

Swissprot Entry: O70582

GenBank Entry: Y14334



Sequence: (701 Residues, 80.6 kDa)

MATYKVKVAT GTDFFSGTLD SISLTIVGTQ GESHKQRLNH FGRDFATGAV DDYTVQCQQD LGELIIIRLH KEPHSFLAKD PWYCNYVQIC APDCRVYHFP AYQWMDGYET LALREATGKI TADDTLPILL EHRQEEIRAK KDFYHWRVFV PGLPNYVDIP SYHPPPRRCR NPNRPEWDGY IPGFPILINI KATRFLNSNL RFSFVKTASF FYRLGPMALA FKLRGLVDRK RSWKRLKDIK NIFPATKSVV SEYVAEHWTE DSFFGYQYLN GINPGLIRRC TQIPDKFPVT DEMVAPFLGE GTCLQAELER GNIYLADYRI LDGIPTVELN GQQQHHCAPM CLLHFGPDGN MMPIAIQLSQ TPGPDCPIFL PNDSEWDWLL AKTWVRYAEF YSHEAVAHLL ESHLIGEAFC LALLRNLPMC HPLYKLLIPH TRYNVQINSI GRALLLNKGG LSARAMSLGL EGFAQVMVRG LSELTYKSLC IPNDFVERGV QDLPGYYFRD DSLAVWYAME RYVTEIITYY YPNDAAVEGD PELQCWVQEI FKECLLGRES SGFPTCLRTI PELIEYVTMV MYTCSARHAA VNSGQLEYTS WMPNFPSSMR NPPMQTKGLT TLQTYMDTLP DVKTTCIVLL VLWTLCREPD DRRPLGHFPD IHFVEEGPRR SIEAFRQNLN QISHNIRQRN KCLTLPYYYL DPVLIENSIS I


Literature:

  • Krieg P., Kinzig A., Heidt M., Marks F., Fuerstenberger G.
    "cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin."
    Biochim. Biophys. Acta 1391: 7-12 (1998)
    more...

  • Sun D., McDonnell M., Chen X.-S., Lakkis M.M., Li H., Isaacs S.N., Elsea S.H., Patel P.I., Funk C.D.
    "Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment."
    J. Biol. Chem. 273: 33540-33547 (1998)
    more...

  • Siebert M., Krieg P., Lehmann W.D., Marks F., Fuerstenberger G.
    "Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes."
    Biochem. J. 355: 97-104 (2001)
    more...

  • Krieg P , Siebert M , Kinzig A , Bettenhausen R , Marks F , Furstenberger G
    "Murine 12(R)-lipoxygenase: functional expression, genomic structure and chromosomal localization."
    FEBS Lett 446: 142-148 (1999)
    more...

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