h-p12-lox
Gene name: ALOX12 or LOG12Species: human (homo sapiens)
Position of Oxygenation: 12
Substrate: arachidonic acid
Stereospecifity: S
Tissue: platelets
Swissprot Entry: P18054
GenBank Entry: M35418
Modeled 3D-Structure: file in pdb format (use Rasmol for viewing)
- View with Webmol by Dirk Walther
To view the structure with the Chime plugin (only available for Windows and Mac), click on the picture at the right.
(To run Chime on Linux computers, you can use the Crossover Plugin.)
Sequence: (662 Residues, 75.5 kDa)
GRYRIRVATG AWLFSGSYNR VQLWLVGTRG EAELELQLRP ARGEEEEFDH DVAEDLGLLQ FVRLRKHHWL VDDAWFCDRI TVQGPGACAE VAFPCYRWVQ GEDILSLPEG TARLPGDNAL DMFQKHREKE LKDRQQIYCW ATWKEGLPLT IAADRKDDLP PNMRFHEEKR LDFEWTLKAG ALEMALKRVY TLLSSWNCLE DFDQIFWGQK SALAEKVRQC WQDDELFSYQ FLNGANPMLL RRSTSLPSRL VLPSGMEELQ AQLEKELQNG SLFEADFILL DGIPANVIRG EKQYLAAPLV MLKMEPNGKL QPMVIQIQPP SPSSPTPTLF LPSDPPLAWL LAKSWVRNSD FQLHEIQYHL LNTHLVAEVI AVATMRCLPG LHPIFKFLIP HIRYTMEINT RARTQLISDG GIFDKAVSTG GGGHVQLLRR AAAQLTYCSL CPPDDLADRG LLGLPGALYA HDALRLWEII ARYVEGIVHL FYQRDDIVKG DPELQAWCRE ITEVGLCQAQ DRGFPVSFQS QSQLCHFLTM CVFTCTAQHA AINQGQLDWY AWVPNAPCTM RMPPPTTKED VTMATVMGSL PDVRQACLQM AISWHLSRRQ PDMVPLGHHK EKYFSGPKPK AVLNQFRTDL EKLEKEITAR NEQLDWPYEY LKPSCIENSV TI
Literature:
- Funk C.D., Furci L., Fitzgerald G.A.
"Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase."
Proc. Natl. Acad. Sci. U.S.A. 87: 5638-5642 (1990)
more...
- Izumi T., Hoshiko S., Radmark O., Samuelsson B.
"Cloning of the cDNA for human 12-lipoxygenase."
Proc. Natl. Acad. Sci. U.S.A. 87: 7477-7481 (1990)
more...
- Funk C.D., Funk L.B., Fitzgerald G.A., Samuelsson B.
"Characterization of human 12-lipoxygenase genes."
Proc. Natl. Acad. Sci. U.S.A. 89: 3962-3966 (1992)
more...