h-5-lox
Gene name: ALOX5 or LOG5Species: human (homo sapiens)
Position of Oxygenation: 5
Substrate: arachidonic acid
Stereospecifity: S
Swissprot Entry: P09917
GenBank Entry: J03600
Modeled 3D-Structure: file in pdb format (use Rasmol for viewing)
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Sequence: (673 Residues, 77.9 kDa)
PSYTVTVATG SQWFAGTDDY IYLSLVGSAG CSEKHLLDKP FYNDFERGAV DSYDVTVDEE LGEIQLVRIE KRKYWLNDDW YLKYITLKTP HGDYIEFPCY RWITGDVEVV LRDGRAKLAR DDQIHILKQH RRKELETRQK QYRWMEWNPG FPLSIDAKCH KDLPRDIQFD SEKGVDFVLN YSKAMENLFI NRFMHMFQSS WNDFADFEKI FVKISNTISE RVMNHWQEDL MFGYQFLNGC NPVLIRRCTE LPEKLPVTTE MVECSLERQL SLEQEVQQGN IFIVDFELLD GIDANKTDPC TLQFLAAPIC LLYKNLANKI VPIAIQLNQI PGDENPIFLP SDAKYDWLLA KIWVRSSDFH VHQTITHLLR THLVSEVFGI AMYRQLPAVH PIFKLLVAHV RFTIAINTKA REQLICECGL FDKANATGGG GHVQMVQRAM KDLTYASLCF PEAIKARGME SKEDIPYYFY RDDGLLVWEA IRTFTAEVVD IYYEGDQVVE EDPELQDFVN DVYVYGMRGR KSSGFPKSVK SREQLSEYLT VVIFTASAQH AAVNFGQYDW CSWIPNAPPT MRAPPPTAKG VVTIEQIVDT LPDRGRSCWH LGAVWALSQF QENELFLGMY PEEHFIEKPV KEAMARFRKN LEAIVSVIAE RNKKKQLPYY YLSPDRIPNS VAI
Literature:
- Matsumoto T., Funk C.D., Raadmark O., Hoeoeg J.-O., Joernvall H., Samuelsson B.
"Molecular cloning and amino acid sequence of human 5-lipoxygenase."
Proc. Natl. Acad. Sci. U.S.A. 85: 26-30 (1988)
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- Ishii S., Noguchi M., Miyano M., Matsumoto T., Noma M.
"Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase."
Biochem. Biophys. Res. Commun. 182: 1482-1490 (1992)
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- Funk C.D., Hoshiko S., Matsumoto T., Raadmark O., Samuelsson B.
"Characterization of the human 5-lipoxygenase gene."
Proc. Natl. Acad. Sci. U.S.A. 86: 2587-2591 (1989)
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- Chen X.S., Funk C.D.
"The N-terminal 'beta-barrel' domain of 5-lipoxygenase is essential for nuclear membrane translocation."
J. Biol. Chem. 276: 811-818 (2001)
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- Dixon RA, Jones RE, Diehl RE, Bennett CD, Kargman S, Rouzer CA
"Cloning of the cDNA for human 5-lipoxygenase."
Proc Natl Acad Sci U S A 85: 416-420 (1988)
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