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h-5-lox - click here to view structure with Chime

h-5-lox

Gene name: ALOX5 or LOG5

Species: human (homo sapiens)

Position of Oxygenation: 5

Substrate: arachidonic acid

Stereospecifity: S

Swissprot Entry: P09917

GenBank Entry: J03600

Modeled 3D-Structure: file in pdb format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther

To view the structure with the Chime plugin (only available for Windows and Mac), click on the picture at the right.
(To run Chime on Linux computers, you can use the Crossover Plugin.)



Sequence: (673 Residues, 77.9 kDa)

PSYTVTVATG SQWFAGTDDY IYLSLVGSAG CSEKHLLDKP FYNDFERGAV DSYDVTVDEE LGEIQLVRIE KRKYWLNDDW YLKYITLKTP HGDYIEFPCY RWITGDVEVV LRDGRAKLAR DDQIHILKQH RRKELETRQK QYRWMEWNPG FPLSIDAKCH KDLPRDIQFD SEKGVDFVLN YSKAMENLFI NRFMHMFQSS WNDFADFEKI FVKISNTISE RVMNHWQEDL MFGYQFLNGC NPVLIRRCTE LPEKLPVTTE MVECSLERQL SLEQEVQQGN IFIVDFELLD GIDANKTDPC TLQFLAAPIC LLYKNLANKI VPIAIQLNQI PGDENPIFLP SDAKYDWLLA KIWVRSSDFH VHQTITHLLR THLVSEVFGI AMYRQLPAVH PIFKLLVAHV RFTIAINTKA REQLICECGL FDKANATGGG GHVQMVQRAM KDLTYASLCF PEAIKARGME SKEDIPYYFY RDDGLLVWEA IRTFTAEVVD IYYEGDQVVE EDPELQDFVN DVYVYGMRGR KSSGFPKSVK SREQLSEYLT VVIFTASAQH AAVNFGQYDW CSWIPNAPPT MRAPPPTAKG VVTIEQIVDT LPDRGRSCWH LGAVWALSQF QENELFLGMY PEEHFIEKPV KEAMARFRKN LEAIVSVIAE RNKKKQLPYY YLSPDRIPNS VAI


Literature:

  • Matsumoto T., Funk C.D., Raadmark O., Hoeoeg J.-O., Joernvall H., Samuelsson B.
    "Molecular cloning and amino acid sequence of human 5-lipoxygenase."
    Proc. Natl. Acad. Sci. U.S.A. 85: 26-30 (1988)
    more...

  • Ishii S., Noguchi M., Miyano M., Matsumoto T., Noma M.
    "Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase."
    Biochem. Biophys. Res. Commun. 182: 1482-1490 (1992)
    more...

  • Funk C.D., Hoshiko S., Matsumoto T., Raadmark O., Samuelsson B.
    "Characterization of the human 5-lipoxygenase gene."
    Proc. Natl. Acad. Sci. U.S.A. 86: 2587-2591 (1989)
    more...

  • Chen X.S., Funk C.D.
    "The N-terminal 'beta-barrel' domain of 5-lipoxygenase is essential for nuclear membrane translocation."
    J. Biol. Chem. 276: 811-818 (2001)
    more...

  • Dixon RA, Jones RE, Diehl RE, Bennett CD, Kargman S, Rouzer CA
    "Cloning of the cDNA for human 5-lipoxygenase."
    Proc Natl Acad Sci U S A 85: 416-420 (1988)
    more...

Show all literature entries related to h-5-lox