h-15-lox-2
Gene name: ALOX15BSpecies: human (homo sapiens)
Position of Oxygenation: 15
Substrate: arachidonic acid
Stereospecifity: S
Swissprot Entry: O15296
GenBank Entry: U78294
Modeled 3D-Structure: file in pdb format (use Rasmol for viewing)
- View with Webmol by Dirk Walther
To view the structure with the Chime plugin (only available for Windows and Mac), click on the picture at the right.
(To run Chime on Linux computers, you can use the Crossover Plugin.)
Sequence: (676 Residues, 75.9 kDa)
MAEFRVRVST GEAFGAGTWD KVSVSIVGTR GESPPLPLDN LGKEFTAGAE EDFQVTLPED VGRVLLLRVH KAPPVLPLLG PLAPDAWFCR WFQLTPPRGG HLLFPCYQWL EGAGTLVLQE GTAKVSWADH HPVLQQQRQE ELQARQEMYQ WKAYNPGWPH CLDEKTVEDL ELNIKYSTAK NANFYLQAGS AFAEMKIKGL LDRKGLWRSL NEMKRIFNFR RTPAAEHAFE HWQEDAFFAS QFLNGLNPVL IRRCHYLPKN FPVTDAMVAS LLGPGTSLQA ELEKGSLFLV DHGILSGIQT NVINGKPQFS AAPMTLLYQS PGCGPLLPLA IQLSQTPGPN SPIFLPTDDK WDWLLAKTWV RNAEFSFHEA LTHLLHSHLL PEVFTLATLR QLPHCHPLFK LLIPHTRYTL HINTLARELL IVPGQVVDRS TGIGIEGFSE LIQRNMKQLN YSLLCLPEDI RTRGVEDIPG YYYRDDGMQI WGAVERFVSE IIGIYYPSDE SVQDDRELQA WVREIFSKGF LNQESSGIPS SLETREALVQ YVTMVIFTCS AKHAAVSAGQ FDSCAWMPNL PPSMQLPPPT SKGLATCEGF IATLPPVNAT CDVILALWLL SKEPGDQRPL GTYPDEHFTE EAPRRSIATF QSRLAQISRG IQERNRGLVL PYTYLDPPLI ENSVSI
Literature:
- Brash A.R., Boeglin W.E., Chang M.S.
"Discovery of a second 15S-lipoxygenase in humans."
Proc. Natl. Acad. Sci. U.S.A. 94: 6148-6152 (1997)
more...
- Tang S., Bhatia B., Maldonado C.J., Yang P., Newman R.A., Liu J., Chandra D., Traag J., Klein R.D., Fischer S.M., Chopra D., Shen J., Zhau H., Chung L.W., Tang D.G.
"Evidence that Arachidonate 15-lipoxygenase 2 is a negative cell-cycle regulator in normal prostate epithelial cells."
J. Biol. Chem. 277: 16189-16201 (2002)
more...
- Brash A.R., Jisaka M., Boeglin W.E., Chang M.S., Keeney D.S., Nanney L.B., Kasper S., Matusik R.J., Olson S.J., Shappell S.B.
"Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues."
Adv. Exp. Med. Biol. 469: 83-89 (1999)
more...
- Jisaka M., Kim R.B., Boeglin W.E., Brash A.R.
"Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2."
J. Biol. Chem. 275: 1287-1293 (2000)
more...