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ss-12-lox

Gene name: ALOX12

Species: pig (sus scorfa)

Position of Oxygenation: 12 / 15

Substrate: arachidonic acid

Stereospecifity: S

Tissue: Leukocyte

Swissprot Entry: P16469

GenBank Entry: M31417

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (662 Residues, 74.9 kDa)

GLYRVRVSTG SSFYAGSQNQ VQLWLVGQHG EAALGWCLRP ARGKETEFSV DVSEYLGPLL FVKLRKRHLL QDDAWFCNWI SVQGPGANGD EFRFPCYRWV EGDRILSLPE GTARTVVDDP QGLFKKHREE ELAERRKLYR WGNWKDGLIL NIASTGIHDL PVDERFLEDK RIDFEASLAK GLADLAVKDS LNVLMSWNSL DSFNRIFWCG QSKLAEQVRD SWKEDALFGY QFLNGTNPML LRHSVELPAR LKFPPGMEEL QAQLEKELQG GTLFEADFSL LDGIKANVIL CSQQYLAVPL VMLKLQPDGK LLPMVIQLQL PREGSPLPPL FLPTDPPMVW LLAKCWVRSS DFQLHELHSH LLRGHLMAEV IAVATMRCLP SIHPIFKLLI PHFRYTMEIN VRARNGLVSD LGIFDQVVST GGGGHVELLR RAAALLTYSS FCPPDDLADR GLLGVESSFY AQDALRLWEV ISRYVEGIVS LHYKTDESVK EDFELQAWCR EFTEIGLLGA QDRGFPVSLQ SKEQLCHFVT MCIFTCTGQH SSNHLGQLDW YTWVPNAPCT MRLPPPTTKD ATLETVMATL PNFHQASLQM SITWQLGRCQ PTMVALGQHE EEYFSGPGPK AVLTKFREEL AALDKDIEVR NAKLALPYEY LRPSRVENSV AI


Literature:

  • Yoshimoto T., Suzuki H., Yamamoto S., Takai T., Yokoyama C., Tanabe T.
    "Cloning and sequence analysis of the cDNA for arachidonate 12-lipoxygenase of porcine leukocytes."
    Proc. Natl. Acad. Sci. U.S.A. 87: 2142-2146 (1990)
    more...

  • Suzuki H., Kishimoto K., Yoshimoto T., Yamamoto S., Kanai F., Ebina Y., Miyatake A., Tanabe T.
    "Site-directed mutagenesis studies on the iron-binding domain and the determinant for the substrate oxygenation site of porcine leukocyte arachidonate 12-lipoxygenase."
    Biochim. Biophys. Acta 1210: 308-316 (1994)
    more...

  • Arakawa T, Oshima T, Kishimoto K, Yoshimoto T, Yamamoto S
    "Molecular structure and function of the porcine arachidonate 12-lipoxygenase gene."
    J Biol Chem 267: 12188-12191 (1992)
    more...