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rn-5-lox

Gene name: ALOX5

Species: rat (rattus norvegicus)

Position of Oxygenation: 5

Substrate: arachidonic acid

Stereospecifity: S

Swissprot Entry: P12527

GenBank Entry: J03960

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (672 Residues, 78.0 kDa)

PSYTVTVATG SQWFAGTDDY IYLSLIGSAG CSEKHLLDKA FYNDFERGGR DSYDVTVDEE LGEIYLVKIE KRKYRLHDDW YLKYITLKTP HDYIEFPCYR WITGEGEIVL RDGCAKLARD DQIHILKQHR RKELETRQKQ YRWMEWNPGF PLSIDAKCHK DLPRDIQFDS EKGVDFVLNY SKAMENLFIN RFMHMFQSSW HDFADFEKIF VKISNTISER VKNHWQEDLM FGYQFLNGCN PVLIKRCTEL PKKLPVTTEM VECSLERQLS LEQEVQEGNI FIVDYELLDG IDANKTDPCT HQFLAAPICL LYKNLANKIV PIAIQLNQTP GEKNPIFLPT DSKYDWLLAK IWVRSSDFHI HQTITHLLRT HLVSEVFGIA MYRQLPAVHP LFKLLVAHVR FTIAINTKAR EQLNCEYGLF DKANATGGGG HVQMVQRAVQ DLTYSSLCFP EAIKARGMDN TEDIPYYFYR DDGLLVWEAI QSFTTEVVSI YYEDDQVVEE DQELQDFVKD VYVYGMRGRK ASGFPKSIKS REKLSEYLTV VIFTASAQHA AVNFGQYDWC SWIPNAPPTM RAPPPTAKGV VTIEQIVDTL PDRGRSCWHL GAVWALSQFQ ENELFLGMYP EEHFIEKPVK EAMIRFRKNL EAIVSVIAER NKNKKLPYYY LSPDRIPNSV AI


Literature:

  • Balcarek J.M., Theisen T.W., Cook M.N., Varrichio A., Hwang S.-M., Strohsacker M.W., Crooke S.T.
    "Isolation and characterization of a cDNA clone encoding rat 5-lipoxygenase."
    J. Biol. Chem. 263: 13937-13941 (1988)
    more...

  • Minor W., Steczko J., Bolin J.T., Otwinowski Z., Axelrod B.
    "Crystallographic determination of the active site iron and its ligands in soybean lipoxygenase L-1."
    Biochemistry 32: 6320-6323 (1993)
    more...

  • Graupera M., Garcia-Pagan J.C., Titos E., Claria J., Massaguer A., Bosch J., Rodes J.
    "5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes."
    Gastroenterology 122: 387-393 (2002)
    more...

  • Benz M., Werz O., Jacob R., Steinhilber D.
    "pH-dependent regulation of leukocyte 5-lipoxygenase activity in inflammatory exudates by albumin."
    Inflamm. Res. 46: 366-372 (1997)
    more...