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rn-12-lox

Gene name: ALOX12

Species: rat (rattus norvegicus)

Position of Oxygenation: 12

Substrate: arachidonic acid

Stereospecifity: S

Swissprot Entry: Q02759

GenBank Entry: L06040

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (662 Residues, 75.3 kDa)

GVYRIRVSTG DSKYAGSNNE VYLWLVGQHG EASLGKLLRP CRDSEAEFKV DVSEYLGPLL FVRVQKWHYL TDDAWFCNWI SVKGPGDQGS EYMFPCYRWV QGRSILSLPE GTGCTVVEDS QGLFRKHREE ELEERRSLYR WGNWKDGSIL NVAAASISDL PVDQRFREDK RIEFEASQVI GVMDTVVNFP INTVTCWKSL DDFNCVFKSG HTKMAERVRN SWKEDAFFGY QFLNGANPMV LKRSTCLPAR LVFPPGMEKL QAQLNKELQK GTLFEADFFL LDGIKANVIL CSQQYLAAPL VMLKLMPDGQ LLPIAIQLEL PKTGSTPPPI FTPSDPPMDW LLAKCWVRSS DLQLHELQAH LLRGHLMAEL FAVATMRCLP SVHPVFKLLV PHLLYTMEIN VRARSDLISE RGFFDKAMST GGGGHLDLLK QAGAFLTYCS LCPPDDLAER GLLDIETCFY AKDALRLWQI MNRYVVGMFN LHYKTDKAVQ DDYELQSWCR EITDIGLQGA QDRGFPTSLQ SRAQACYFIT MCIFTCTAQH SSVHLGQLDW FYWVPNAPCT MRLPPPTTKE ATMEKLMATL PNPNQSTLQI NVVWLLGRRQ AVMVPLGQHS EEHFPNPEAK AVLKKFREEL AALDKEIEIR NKSLDIPYEY LRPSMVENSV AI


Literature:

  • Hada T., Hagiya H., Suzuki H., Arakawa T., Nakamura M., Matsuda S., Yoshimoto T., Yamamoto S., Azekawa T., Morita Y., Ishimura K., Kim H.Y.
    "Arachidonate 12-lipoxygenase of rat pineal glands: catalytic properties and primary structure deduced from its cDNA."
    Biochim. Biophys. Acta 1211: 221-228 (1994)
    more...

  • Watanabe T., Medina J.F., Haeggstroem J.Z., Raadmark O.P., Samuelsson B.
    "Molecular cloning of a 12-lipoxygenase cDNA from rat brain."
    Eur. J. Biochem. 212: 605-612 (1993)
    more...

  • Watanabe T., Haeggstrom J.Z.
    "Rat 12-lipoxygenase: mutations of amino acids implicated in the positional specificity of 15- and 12-lipoxygenases."
    Biochem. Biophys. Res. Commun. 192: 1023-1029 (1993)
    more...