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oc-15-lox

Gene name: ALOX15

Species: rabbit (oryctolagus cuniculus)

Position of Oxygenation: 15

Substrate: arachidonic acid

Stereospecifity: S

Swissprot Entry: P12530

GenBank Entry: M27214

PDB Entry: 1LOX

IMB Jena: 1LOX

Structure: file in pdb format (use Rasmol for viewing)

View Structure with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (662 Residues, 75.2 kDa)

GVYRVCVSTG ASIYAGSKNK VELWLVGQHG EVELGSCLRP TRNKEEEFKV NVSKYLGSLL FVRLRKKHFL KEDAWFCNWI SVQALGAAED KYWFPCYRWV VGDGVQSLPV GTGCTTVGDP QGLFQKHREQ ELEERRKLYQ WGSWKEGLIL NVAGSKLTDL PVDERFLEDK KIDFEASLAW GLAELALKNS LNILAPWKTL DDFNRIFWCG RSKLARRVRD SWQEDSLFGY QFLNGANPML LRRSVQLPAR LVFPPGMEEL QAQLEKELKA GTLFEADFAL LDNIKANVIL YCQQYLAAPL VMLKLQPDGK LMPMVIQLHL PKIGSSPPPL FLPTDPPMVW LLAKCWVRSS DFQVHELNSH LLRGHLMAEV FTVATMRCLP SIHPVFKLIV PHLRYTLEIN VRARNGLVSD FGIFDQIMST GGGGHVQLLQ QAGAFLTYRS FCPPDDLADR GLLGVESSFY AQDALRLWEI ISRYVQGIMG LYYKTDEAVR DDLELQSWCR EITEIGLQGA QKQGFPTSLQ SVAQACHFVT MCIFTCTGQH SSIHLGQLDW FTWVPNAPCT MRLPPPTTKD ATLETVMATL PNLHQSSLQM SIVWQLGRDQ PIMVPLGQHQ EEYFSGPEPR AVLEKFREEL AIMDKEIEVR NEKLDIPYEY LRPSIVENSV AI


Literature:

  • Gillmor S.A., Villasenor A., Fletterick R., Sigal E., Browner M.F.
    "The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity."
    Nat. Struct. Biol. 4: 1003-1009 (1997)
    more...

  • Fleming J., Thiele B.J., Chester J., O'Prey J., Janetzki S., Aitken A., Anton I.A., Rapoport S.M., Harrison P.R.
    "The complete sequence of the rabbit erythroid cell-specific 15-lipoxygenase mRNA: comparison of the predicted amino acid sequence of the erythrocyte lipoxygenase with other lipoxygenases."
    Gene 79: 181-188 (1989)
    more...

  • O'Prey J., Chester J., Thiele B.J., Janetzki S., Prehn S., Fleming J., Harrison P.R.
    "The promoter structure and complete sequence of the gene encoding the rabbit erythroid cell-specific 15-lipoxygenase."
    Gene 84: 493-499 (1989)
    more...

  • Berger M., Schwarz K., Thiele H., Reimann I., Huth A., Borngraber S., Kuhn H., Thiele B.J.
    "Simultaneous expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits."
    J. Mol. Biol. 278: 935-948 (1998)
    more...