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oc-12-lox

Gene name: ALOX12

Species: rabbit (oryctolagus cuniculus)

Position of Oxygenation: 12

Substrate: arachidonic acid

Stereospecifity: S

Swissprot Entry: O19043

GenBank Entry: Z97654

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (662 Residues, 75.1 kDa)

GVYRVCVSTG ASIYAGSKNK VELWLVGQHG EVELGSCLRP SRNKEEEFKV NVSKYLGSLL FVKLRKKHFL KEDAWFCNWI SVQALGAAED KYWFPCYRWV VGDGVQSLPV GTGCTTVGDP QGLFQKHREQ ELEERRKLYQ WGSWKEGLIL NVAGSKLTDL PVDERFLEDK KIDFEASLAW GLAELALKNS LNILAPWKTL DDFNRIFWCG RSKLARRVRD SWQEDSLFGY QFLNGANPML LRRSVQLPAR LVFPPGMEEL QAQLEKELKA GTLFEADFAL LDNIKANVIL YCQQYLAAPL VMLKLQPDGK LMPMVIQLHL PKIGSSPPPL FLPTDPPMVW LLAKCWVRSS DLQVHELNSH LLRGHLMAEV FTVATMRCLP SIHPVFKLIV PHLRYTLEIN VRARNGLVSD FGIFDQIMST GGGGHVQLLQ QAGAFLTYRS FCPPDDLADR GLLGVESSFY AQDALRLWEI ISRYVQGIMG LYYKTDEAVR DDLELQSWCR EITEIGLQGA QKQGFPTSLQ SVAQACHFVT MCIFTCTGQH SSIHLGQLDW FTWVPNAPCT MRLPPPTTKD ATLETVMATL PNLHQSSLQM SIVWQLGRDQ PIMVPLGQHQ EEYFSGPEPR AVLEKFREEL AIMDKEIEVR NEKLDIPYEY LRPSIVENSV AI


Literature:

  • Berger M., Schwarz K., Thiele H., Reimann I., Huth A., Borngraber S., Kuhn H., Thiele B.J.
    "Simultaneous expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits."
    J. Mol. Biol. 278: 935-948 (1998)
    more...