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ma-5-lox

Gene name: ALOX5

Species: golden hamster (mesocricetus auratus)

Position of Oxygenation: 5

Substrate: arachidonic acid

Stereospecifity: S

Swissprot Entry: P51399

GenBank Entry: U43333

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (672 Residues, 77.7 kDa)

PSYTVTVATG SQWFAGTDDY IYLSLIGSAG CSEKHLLDKA FYNDFERGAV DSYDVTVDEE LGEIQLVRIE KRKYWLHDDW YLKYITLKTP TDYIEFPCYR WITGEGEIVL RDGRAKLARD DQIHILKQHR RKELEARQKQ YRWMEWNPGF PLSIDAKCHK DLPRDIQFDS EKGVDFVLNY SKAMENLFIN RFMHMFQSSW NDFADFEKIF VKISNTISER VKNHWQEDLM FGYQFLNGCN PVLIKRCREL PQKLPVTTEM VECSLERHLS LEQEVQEGNI FIVDYELLDG IDANKTDPCT HQFLAAPICL LYKNLANKIV PIAIQLNQAP GEKNPIFLPS DAKYDWLLAK IWVRSSDFHV HQTITHLLCT HLVSEVFGIA MYRQLPAVHP IFKLLVAHVR FTIAINTKAR EQLICEYGLF DKANATGGGG HVQMVQRAVQ DLTYSSLCFP EAIKARGMDS TEDIPYYFYR DDGLLVWEAI QSFTSEVVSI YYEDDQVVME DQELQDFVKD VYVYGMRGRK ASGFPKSIKS REKLSEYLTV VIFTASAQHA AVNFGQYDWC SWIPNAPPTM RAPPATAKGV VTIEQIVATL PDRGRSCWHL GAVWALSQFQ ENELFLGMYP EEHFIEKPVK EAMTRFRKNL EAIVNVIAER NKNKKLPYYY LSPDRIPNSV AI


Literature:

  • Kitzler J.W., Eling T.E.
    "Cloning, sequencing and expression of a 5-lipoxygenase from Syrian hamster embryo fibroblasts."
    Prostaglandins Leukot. Essent. Fatty Acids 55: 269-277 (1996)
    more...

  • Gimeno G., Carpentier P.H., Desquand-Billiald S., Finet M., Hanf R.
    "Respective role of lipoxygenase and nitric oxide-synthase pathways in plasma histamine-induced macromolecular leakage in conscious hamsters."
    Br. J. Pharmacol. 126: 1801-1809 (1999)
    more...

  • Lehr H.A., Kress E., Menger M.D.
    "Involvement of 5-lipoxygenase products in cigarette smoke-induced leukocyte/endothelium interaction in hamsters."
    Int. J. Microcirc. Clin. Exp. 12: 61-73 (1993)
    more...