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m-p12-lox

Gene name: ALOX12 or ALOX12P

Species: mouse (mus musculus)

Position of Oxygenation: 12

Substrate: arachidonic acid

Stereospecifity: S

Tissue: platelets

Swissprot Entry: P39655

GenBank Entry: U04334

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (662 Residues, 75.2 kDa)

GAYRVRVVTG AWLFSGSLNL VRLWLVGEHR EAKLELQLRP ARGKEEEFDF DVPEDLGPLQ FVKLHKQHTV VDDAWFCNLI TVQGPGTSAE AVFPCYRWVQ GEGILSLPEG QARLAGDNAL DVFQKYREKE LKERQQTYCW ATWKEGLPQT IAADCKDDLP PNMRFHEEKR LDFEWTLKAG VLEMGLKRVY TLLRSWNHLE DFDQIFWGQK SALAEKVHQC WQEDELFGYQ FLNGANPMLL RRSTSLPSRL VLPSGMEELQ AQLEKELKNG SLFEADFILL DGIPANVIRG EPQYLAAPLV MLRMDPGGKL LPMAIQIQPP NPSSPAPTLF LPSDPPLAWL LAKIWVRNSD FQLQELQFHL LNTHLVAEVI AVATMRCLPG LHPIFKLLVP HIRYTMEINT RTRTQLISDG GIFDQVVSTG GGGHVQLLTR AVAQLTYHSL CPPDDLANRG LLRIPSALYA RDALQLWEVT ARYVKGMVHL FYQSDDIVRG DPELQAWCRE ITEVGLCHAQ DRGFPVSFQS RAQLCHFLTM CVFTCTAQHA AINQGQLDWY GWVPNAPCTM RMPPPTSKDD VTMETVMGSL PDVQKACLQM TITWHLGRLQ PDMVPLGHHT EKYFSDPRTK AVLSQFQADL DNLEKEITAR NEQLDLPYEY LKPSRIENSI TI


Literature:

  • Chen X.-S., Kurre U., Jenkins N.A., Copeland N.G., Funk C.D.
    "cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases."
    J. Biol. Chem. 269: 13979-13987 (1994)
    more...

  • Siebert M., Krieg P., Lehmann W.D., Marks F., Fuerstenberger G.
    "Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes."
    Biochem. J. 355: 97-104 (2001)
    more...

  • Buerger F., Krieg P., Marks F., Fuerstenberger G.
    "Positional- and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymes."
    Biochem. J. 348: 329-335 (2000)
    more...