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m-l12-lox

Gene name: ALOX12L or ALOX15

Species: mouse (mus musculus)

Position of Oxygenation: 12 / 15

Substrate: arachidonic acid

Stereospecifity: S

Tissue: leucocyte

Swissprot Entry: P39654

GenBank Entry: U04331

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (662 Residues, 75.3 kDa)

GVYRIRVSTG DSVYAGSNNE VYLWLIGQHG EASLGKLFRP CRNSEAEFKV DVSEYLGPLL FVRVQKWHYL KEDAWFCNWI SVKGPGDQGS EYTFPCYRWV QGTSILNLPE GTGCTVVEDS QGLFRNHREE ELEERRSLYR WGNWKDGTIL NVAATSISDL PVDQRFREDK RLEFEASQVL GTMDTVINFP KNTVTCWKSL DDFNYVFKSG HTKMAERVRN SWKEDAFFGY QFLNGANPMV LKRSTCLPAR LVFPPGMEKL QAQLDEELKK GTLFEADFFL LDGIKANVIL CSQQYLAAPL VMLKLQPDGQ LLPIAIQLEL PKTGSTPPPI FTPLDPPMDW LLAKCWVRSS DLQLHELQAH LLRGHLVAEV FAVATMRCLP SVHPVFKLLV PHLLYTMEIN VRARSDLISE RGFFDKVMST GGGGHLDLLK QAGAFLTYSS LCPPDDLAER GLLDIDTCFY AKDALQLWQV MNRYVVGMFD LYYKTDQAVQ DDYELQSWCQ EITEIGLQGA QDRGFPTSLQ SRAQACHFIT MCIFTCTAQH SSIHLGQLDW FYWVPNAPCT MRLPPPKTKD ATMEKLMATL PNPNQSTLQI NVVWLLGRRQ AVMVPLGQHS EEHFPNPEAK AVLKKFREEL AALDKEIEIR NKSLDIPYEY LRPSLVENSV AI


Literature:

  • Chen X.-S., Kurre U., Jenkins N.A., Copeland N.G., Funk C.D.
    "cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases."
    J. Biol. Chem. 269: 13979-13987 (1994)
    more...

  • Freire-Moar J., Alavi-Nassab A., Ng M., Mulkins M., Sigal E.
    "Cloning and characterization of a murine macrophage lipoxygenase."
    Biochim. Biophys. Acta 1254: 112-116 (1995)
    more...

  • Buerger F., Krieg P., Marks F., Fuerstenberger G.
    "Positional- and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymes."
    Biochem. J. 348: 329-335 (2000)
    more...