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m-e12-lox

Gene name: ALOX12-PS2 or ALOXE

Species: mouse (mus musculus)

Position of Oxygenation: 12

Substrate: arachidonyl ester

Stereospecifity: S

Tissue: epidermis

Swissprot Entry: P55249

GenBank Entry: X99252

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (662 Residues, 75.5 kDa)

MVKYKILVAT GDSVFAGSAN LVHLWLVGEH GEADLGKQLR PLLGRKTELE VDVPLHLGRL LAVKLRKQKG LLDSDWFCKS ITVQGPGTQG EAFFPCYSWV QGKETICLTE GTALKVTDDT QNLFRKYREQ ELENRRNVYR WGSWKEGLIL PIAGSTERDL PRNQRFMKDK DLDFSLSLVK ELKNFAIKGT LDFVSRVQKL EDYQKVFPHT KTALPERVRG SWKEDALFGY QFLNGANPML LRRSMRLPAR LVLPPGMEDV QTQLEKELKA GSLFEVDFSL LDGVKPNIII FKQQYVTAPL VMLKLQPDGR LLPMVIQLQP PRHGCPPPLL FLPSDPPMAW LLAKIWVRSS DFQLHQLQSH LLRGHLMAEV ISVATMRSLP SLHPIYKLLA PHFRYTMEIN TLARNNLVSE WGIFDLVVST GSGGHVDILQ RATSCLTYRS FCPPDDLADR GLVGVKSSLY AQDALRLWEI ISRYVERMVE LFYRSDTDVK EDPELQVWCR EVTEVGLLGA QDRGFPLSLE SRAELCRFVA MCIFTCTGQH ASTHLGQLDW YAWIPNGPCT MRKPPPISKD VTERDIVDSL PCLQQARMQI TVTKFLGRRQ PVMVALGQHK EEYFSGPRPR DVLKQFQEEL AIMDKEIEVR NASLDLPYEY LRPSLVENSV TI


Literature:

  • Kinzig A., Fuerstenberger G., Mueller F., Vogel S., Mueller-Decker K., Mincheva A., Lichter P., Marks F., Krieg P.
    "Murine epidermal lipoxygenase (Aloxe) encodes a 12-lipoxygenase isoform."
    FEBS Lett. 402: 162-166 (1997)
    more...

  • van Dijk K.W., Steketee K., Havekes L., Frants R., Hofker M.
    "Genomic and cDNA cloning of a novel mouse lipoxygenase gene."
    Biochim. Biophys. Acta 1259: 4-8 (1995)
    more...

  • Funk C.D., Keeney D.S., Oliw E.H., Boeglin W.E., Brash A.R.
    "Functional expression and cellular localization of a mouse epidermal lipoxygenase."
    J. Biol. Chem. 271: 23338-23344 (1996)
    more...

  • Siebert M., Krieg P., Lehmann W.D., Marks F., Fuerstenberger G.
    "Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes."
    Biochem. J. 355: 97-104 (2001)
    more...