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m-8-lox

Gene name: Alox15B or Alox8

Species: mouse (mus musculus)

Position of Oxygenation: 8

Substrate: arachidonic acid

Stereospecifity: S

Tissue: epidermis

Swissprot Entry: O35936

GenBank Entry: Y14696

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (677 Residues, 76.2 kDa)

MAKCRVRVST GEACGAGTWD KVSVSIVGTH GESPLVPLDH LGKEFSAGAE EDFEVTLPQD VGTVLMLRVH KAPPEVSLPL MSFRSDAWFC RWFELEWLPG AALHFPCYQW LEGAGELVLR EGAAKVSWQD HHPTLQDQRQ KELESRQKMY SWKTYIEGWP RCLDHETVKD LDLNIKYSAM KNAKLFFKAH SAYTELKVKG LLDRTGLWRS LREMRRLFNF RKTPAAEYVF AHWQEDAFFA SQFLNGINPV LIRRCHSLPN NFPVTDEMVA PVLGPGTSLQ AELEKGSLFL VDHGILSGVH TNILNGKPQF SAAPMTLLHQ SSGSGPLLPI AIQLKQTPGP DNPIFLPSDD TWDWLLAKTW VRNSEFYIHE AVTHLLHAHL IPEVFALATL RQLPRCHPLF KLLIPHIRYT LHINTLAREL LVAPGKLIDK STGLGTGGFS DLIKRNMEQL NYSVLCLPED IRARGVEDIP GYYYRDDGMQ IWGAIKSFVS EIVSIYYPSD TSVQDDQELQ AWVREIFSEG FLGRESSGMP SLLDTREALV QYITMVIFTC SAKHAAVSSG QFDSCVWMPN LPPTMQLPPP TSKGQARPES FIATLPAVNS SSYHIIALWL LSAEPGDQRP LGHYPDEHFT EDAPRRSVAA FQRKLIQISK GIRERNRGLA LPYTYLDPPL IENSVSI


Literature:

  • Jisaka M., Kim R.B., Boeglin W.E., Nanney L.B., Brash A.R.
    "Molecular cloning and functional expression of a phorbol ester-inducible 8S-lipoxygenase from mouse skin."
    J. Biol. Chem. 272: 24410-24416 (1997)
    more...

  • Krieg P., Kinzig A., Heidt M., Marks F., Fuerstenberger G.
    "cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin."
    Biochim. Biophys. Acta 1391: 7-12 (1998)
    more...

  • Buerger F., Krieg P., Kinzig A., Schurich B., Marks F., Fuerstenberger G.
    "Constitutive expression of 8-lipoxygenase in papillomas and clastogenic effects of lipoxygenase-derived arachidonic acid metabolites in keratinocytes."
    Mol. Carcinog. 24: 108-117 (1999)
    more...

  • Jisaka M., Kim R.B., Boeglin W.E., Brash A.R.
    "Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2."
    J. Biol. Chem. 275: 1287-1293 (2000)
    more...