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m-5-lox

Gene name: ALOX5

Species: mouse (mus musculus)

Position of Oxygenation: 5

Substrate: arachidonic acid

Stereospecifity: S

Tissue: peritoneal cavity

Swissprot Entry: P48999

GenBank Entry: L42198

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (673 Residues, 77.9 kDa)

PSYTVTVATG SQWFAGTDDY IYLSLIGSAG CSEKHLLDKA FYNDFERGAV DSYDVTVDEE LGEIYLVKIE KRKYWLHDDW YLKYITLKTP HGDYIEFPCY RWITGEGEIV LRDGRAKLAR DDQIHILKQH RRKELEARQK QYRWMEWNPG FPLSIDAKCH KDLPRDIQFD SEKGVDFVLN YSKAMENLFI NRFMHMFQSS WHDFADFEKI FVKISNTISE RVKNHWQEDL MFGYQFLNGC NPVLIKRCTA LPPKLPVTTE MVECSLERQL SLEQEVQEGN IFIVDYELLD GIDANKTDPC THQFLAAPIC LLYKNLANKI VPIAIQLNQT PGESNPIFLP TDSKYDWLLA KIWVRSSDFH VHQTITHLLR THLVSEVFGI AMYRQLPAVH PLFKLLVAHV RFTIAINTKA REQLICEYGL FDKANATGGG GHVQMVQRAV QDLTYSSLCF PEAIKARGMD STEDMPFYFY RDDGLLVWEA IQSFTMEVVS IYYENDQVVE EDQELQDFVK DVYVYGMRGK KASGFPKSIK SREKLSEYLT VVIFTASAQH AAVNFGQYDW CSWIPNAPPT MRAPPPTAKG VVTIEQIVDT LPDRGRSCWH LGAVWALSQF QENELFLGMY PEEHFIEKPV KEAMIRFRKN LEAIISVIAE RNKNKKLPYY YLSPDRIPNS VAI


Literature:

  • Chen X.-S., Naumann T.A., Kurre U., Jenkins N.A., Copeland N.G., Funk C.D.
    "cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase."
    J. Biol. Chem. 270: 17993-17999 (1995)
    more...

  • Chen X.S., Funk C.D.
    "The N-terminal 'beta-barrel' domain of 5-lipoxygenase is essential for nuclear membrane translocation."
    J. Biol. Chem. 276: 811-818 (2001)
    more...