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h-p12-lox

Gene name: ALOX12 or LOG12

Species: human (homo sapiens)

Position of Oxygenation: 12

Substrate: arachidonic acid

Stereospecifity: S

Tissue: platelets

Swissprot Entry: P18054

GenBank Entry: M35418

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (662 Residues, 75.5 kDa)

GRYRIRVATG AWLFSGSYNR VQLWLVGTRG EAELELQLRP ARGEEEEFDH DVAEDLGLLQ FVRLRKHHWL VDDAWFCDRI TVQGPGACAE VAFPCYRWVQ GEDILSLPEG TARLPGDNAL DMFQKHREKE LKDRQQIYCW ATWKEGLPLT IAADRKDDLP PNMRFHEEKR LDFEWTLKAG ALEMALKRVY TLLSSWNCLE DFDQIFWGQK SALAEKVRQC WQDDELFSYQ FLNGANPMLL RRSTSLPSRL VLPSGMEELQ AQLEKELQNG SLFEADFILL DGIPANVIRG EKQYLAAPLV MLKMEPNGKL QPMVIQIQPP SPSSPTPTLF LPSDPPLAWL LAKSWVRNSD FQLHEIQYHL LNTHLVAEVI AVATMRCLPG LHPIFKFLIP HIRYTMEINT RARTQLISDG GIFDKAVSTG GGGHVQLLRR AAAQLTYCSL CPPDDLADRG LLGLPGALYA HDALRLWEII ARYVEGIVHL FYQRDDIVKG DPELQAWCRE ITEVGLCQAQ DRGFPVSFQS QSQLCHFLTM CVFTCTAQHA AINQGQLDWY AWVPNAPCTM RMPPPTTKED VTMATVMGSL PDVRQACLQM AISWHLSRRQ PDMVPLGHHK EKYFSGPKPK AVLNQFRTDL EKLEKEITAR NEQLDWPYEY LKPSCIENSV TI


Literature:

  • Funk C.D., Furci L., Fitzgerald G.A.
    "Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase."
    Proc. Natl. Acad. Sci. U.S.A. 87: 5638-5642 (1990)
    more...

  • Izumi T., Hoshiko S., Radmark O., Samuelsson B.
    "Cloning of the cDNA for human 12-lipoxygenase."
    Proc. Natl. Acad. Sci. U.S.A. 87: 7477-7481 (1990)
    more...

  • Funk C.D., Funk L.B., Fitzgerald G.A., Samuelsson B.
    "Characterization of human 12-lipoxygenase genes."
    Proc. Natl. Acad. Sci. U.S.A. 89: 3962-3966 (1992)
    more...