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h-5-lox

Gene name: ALOX5 or LOG5

Species: human (homo sapiens)

Position of Oxygenation: 5

Substrate: arachidonic acid

Stereospecifity: S

Swissprot Entry: P09917

GenBank Entry: J03600

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (673 Residues, 77.9 kDa)

PSYTVTVATG SQWFAGTDDY IYLSLVGSAG CSEKHLLDKP FYNDFERGAV DSYDVTVDEE LGEIQLVRIE KRKYWLNDDW YLKYITLKTP HGDYIEFPCY RWITGDVEVV LRDGRAKLAR DDQIHILKQH RRKELETRQK QYRWMEWNPG FPLSIDAKCH KDLPRDIQFD SEKGVDFVLN YSKAMENLFI NRFMHMFQSS WNDFADFEKI FVKISNTISE RVMNHWQEDL MFGYQFLNGC NPVLIRRCTE LPEKLPVTTE MVECSLERQL SLEQEVQQGN IFIVDFELLD GIDANKTDPC TLQFLAAPIC LLYKNLANKI VPIAIQLNQI PGDENPIFLP SDAKYDWLLA KIWVRSSDFH VHQTITHLLR THLVSEVFGI AMYRQLPAVH PIFKLLVAHV RFTIAINTKA REQLICECGL FDKANATGGG GHVQMVQRAM KDLTYASLCF PEAIKARGME SKEDIPYYFY RDDGLLVWEA IRTFTAEVVD IYYEGDQVVE EDPELQDFVN DVYVYGMRGR KSSGFPKSVK SREQLSEYLT VVIFTASAQH AAVNFGQYDW CSWIPNAPPT MRAPPPTAKG VVTIEQIVDT LPDRGRSCWH LGAVWALSQF QENELFLGMY PEEHFIEKPV KEAMARFRKN LEAIVSVIAE RNKKKQLPYY YLSPDRIPNS VAI


Literature:

  • Matsumoto T., Funk C.D., Raadmark O., Hoeoeg J.-O., Joernvall H., Samuelsson B.
    "Molecular cloning and amino acid sequence of human 5-lipoxygenase."
    Proc. Natl. Acad. Sci. U.S.A. 85: 26-30 (1988)
    more...

  • Ishii S., Noguchi M., Miyano M., Matsumoto T., Noma M.
    "Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase."
    Biochem. Biophys. Res. Commun. 182: 1482-1490 (1992)
    more...

  • Funk C.D., Hoshiko S., Matsumoto T., Raadmark O., Samuelsson B.
    "Characterization of the human 5-lipoxygenase gene."
    Proc. Natl. Acad. Sci. U.S.A. 86: 2587-2591 (1989)
    more...

  • Chen X.S., Funk C.D.
    "The N-terminal 'beta-barrel' domain of 5-lipoxygenase is essential for nuclear membrane translocation."
    J. Biol. Chem. 276: 811-818 (2001)
    more...

  • Dixon RA, Jones RE, Diehl RE, Bennett CD, Kargman S, Rouzer CA
    "Cloning of the cDNA for human 5-lipoxygenase."
    Proc Natl Acad Sci U S A 85: 416-420 (1988)
    more...