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h-15-lox

Gene name: ALOX15 or LOG15

Species: human (homo sapiens)

Position of Oxygenation: 15

Substrate: arachidonic acid

Stereospecifity: S

Swissprot Entry: P16050

GenBank Entry: M23892

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (661 Residues, 74.7 kDa)

GLYRIRVSTG ASLYAGSNNQ VQLWLVGQHG EAALGKRLWP ARGKETELKV EVPEYLGPLL FVKLRKRHLL KDDAWFCNWI SVQGPGAGDE VRFPCYRWVE GNGVLSLPEG TGRTVGEDPQ GLFQKHREEE LEERRKLYRW GNWKDGLILN MAGAKLYDLP VDERFLEDKR VDFEVSLAKG LADLAIKDSL NVLTCWKDLD DFNRIFWCGQ SKLAERVRDS WKEDALFGYQ FLNGANPVVL RRSAHLPARL VFPPGMEELQ AQLEKELEGG TLFEADFSLL DGIKANVILC SQQHLAAPLV MLKLQPDGKL LPMVIQLQLP RTGSPPPPLF LPTDPPMAWL LAKCWVRSSD FQLHELQSHL LRGHLMAEVI VVATMRCLPS IHPIFKLIIP HLRYTLEINV RARTGLVSDM GIFDQIMSTG GGGHVQLLKQ AGAFLTYSSF CPPDDLADRG LLGVKSSFYA QDALRLWEII YRYVEGIVSL HYKTDVAVKD DPELQTWCRE ITEIGLQGAQ DRGFPVSLQA RDQVCHFVTM CIFTCTGQHA SVHLGQLDWY SWVPNAPCTM RLPPPTTKDA TLETVMATLP NFHQASLQMS ITWQLGRRQP VMVAVGQHEE EYFSGPEPKA VLKKFREELA ALDKEIEIRN AKLDMPYEYL RPSVVENSVA I


Literature:

  • Sigal E., Craik C.S., Highland E., Grunberger D., Costello L.L., Dixon R.A.F., Nadel J.A.
    "Molecular cloning and primary structure of human 15-lipoxygenase."
    Biochem. Biophys. Res. Commun. 157: 457-464 (1988)
    more...

  • Sigal E., Grunberger D., Craik C.S., Caughey G.H., Nadel J.A.
    "Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases."
    J. Biol. Chem. 263: 5328-5332 (1988)
    more...

  • Izumi T., Raadmark O., Joernvall H., Samuelsson B.
    "Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes."
    Eur. J. Biochem. 202: 1231-1238 (1991)
    more...

  • Gan Q.F., Browner M.F., Sloane D.L., Sigal E.
    "Defining the arachidonic acid binding site of human 15-lipoxygenase. Molecular modeling and mutagenesis."
    J. Biol. Chem. 271: 25412-25418 (1996)
    more...