Deutsches Krebsforschungszentrum 
German Cancer Resarch CenterLOX-DB - LipOXygenases DataBase
Lipoxygenases...
What are Lipoxygenases?
Lipoxygenases and
cancer research
Database...
Search
Display all entries
Alignments
Sequence Comparison
Blast Search
Search Literature
Search Literature (adv.)
Misc...
Image Gallery
Links
Forum
Contact
Guestbook
Home

cc-13-lox

Gene name: none

Species: cucumber (cucumis sativus)

Position of Oxygenation: 13

Substrate: linoleic acid

Stereospecifity: S

Tissue: lipid bodies

Swissprot Entry: Q42710

GenBank Entry: X92890

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (878 Residues, 99.8 kDa)

MFGIGKNIIE GALNTTGDLA GSVINAGGNI LDRVSSLGGN KIKGKVILMR SNVLDFTEFH SNLLDNFTEL LGGGVSFQLI SATHTSNDSR GKVGNKAYLE RWLTSIPPLF AGESVFQINF QWDENFGFPG AFFIKNGHTS EFFLKSLTLD DVPGYGRVHF DCNSWVYPSG RYKKDRIFFA NHVYLPSQTP NPLRKYREEE LWNLRGDGTG ERKEWDRIYD YDVYNDIADP DVGDHRPILG GTTEYPYPRR GRTGRPRSRR DHNYESRLSP IMSLDIYVPK DENFGHLKMS DFLGYTLKAL SISIKPGLQS IFDVTPNEFD NFKEVDNLFE RGFPIPFNAF KTLTEDLTPP LFKALVRNDG EKFLKFPTPE VVKDNKIGWS TDEEFAREML AGPNPLLIRR LEAFPPTSKL DPNVYGNQNS TITEEHIKHG LDGLTVDEAM KQNRLYIVDF HDALMPYLTR MNATSTKTYA TRTLLLLKDD GTLKPLVIEL ALPHPQGDQL GAISKLYFPA ENGVQKSIWQ LAKAYVTVND VGYHQLISHW LHTHAVLEPF VIATHRQLSV LHPIHKLLVP HYKDTMFINA SARQVLINAN GLIETTHYPS KYSMELSSIL YKDWTFPDQA LPNNLMKRGL AVEDSSAPHG LRLLINDYPF AVDGLDIWSA IKTWVQDYCC LYYKDDNAVQ NDFELQSWWN ELREKGHADK KHEPWWPKMQ TLSELIESCT TIIWIASALH AAVNFGQYPY GGYILNRPTT SRRFMPEVGT AEYKELESNP EKAFLRTICS ELQALVSISI IEILSKHASD EVYLGQRASI DWTSDKIALE AFEKFGKNLF EVENRIMERN KEVNLKNRSG PVNLPYTLLV PSSNEGLTGR GIPNSISI


Literature:

  • Hohne M., Nellen A., Schwennesen K., Kindl H.
    "Lipid body lipoxygenase characterized by protein fragmentation, cDNA sequence and very early expression of the enzyme during germination of cucumber seeds."
    Eur. J. Biochem. 241: 6-11 (1996)
    more...

  • Hornung E., Walther M., Kuhn H., Feussner I.
    "Conversion of cucumber linoleate 13-lipoxygenase to a 9-lipoxygenating species by site-directed mutagenesis."
    Proc. Natl. Acad. Sci. U.S.A. 96: 4192-4197 (1999)
    more...