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bt-l12-lox

Gene name: ALOX12

Species: bovine (bos taurus)

Position of Oxygenation: 12 / 15

Substrate: arachidonic acid

Stereospecifity: S

Swissprot Entry: P27479

GenBank Entry: M81320

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (662 Residues, 74.9 kDa)

GLYRVRVSTG SSFCAGSNNQ VHLWLVGEHG EAALGWAVRP ARGKEVEFQV DVSEYLGRLL FVKLRKRHLL SDDAWFCNWI SVQGPGASGN EFRFPCYRWV EGDGILSLPE GTGRTVVDDP QGLFKKHREE ELAERRKLYR WGNWKDGLIL NIAGATINDL PVDERFLEDK RIDFEASLTK GLADLAIKDS LNILTCWKSL DDFNRIFWCG QSKLAERVRD SWKEDALFGY QFLNGTNPML LRRSVRLPAR LEFPPGMGEL QAELEKELQQ GTLFEADFSL LMGIKANVIL CTQQYVAAPL VMLKLQPDGK LLPMAIQLQL PHKGSPPPPL FLPTDPPMTW LLAKCWVRSS DFQLHELHSH LLRGHLVAEV IAVATMRCLP SIHPMFKLLI PHLRYTMEIN IRARTGLVSD SGVFDQVVST GGGGHVELLQ RAGAFLTYSS FCPPDDLADR GLLGVKSSFY AQDALRLWEI LSRYVEGIVS LHYKTDESVR DDIELQAWCR DITEIGLLGA QDRGFPVTLQ SKDQLCHFVT MCIFTCTGQH SSTHLGQLDW YSWVPNAPCT MRLPPPTTKD VTLEKVMATL PNFHQASLQM SITWQLGRRQ PIMVALGQHE EEYFSGPEPK AVLKKFREEL AALEKDIEIR NAQLDWPYEY LRPSLVENSV AI


Literature:

  • de Marzo N., Sloan D.L., Dicharry S., Highland E., Sigal E.
    "Cloning and expression of an airway epithelial 12-lipoxygenase."
    Am. J. Physiol. 262: L198-L207 (1992)
    more...

  • Liminga M., Oliw E.
    "cDNA cloning of 15-lipoxygenase type 2 and 12-lipoxygenases of bovine corneal epithelium."
    Biochim Biophys Acta 1437:124-135 1437: 124-135 (1999)
    more...

  • Liminga M., Oliw E.H.
    "Studies of lipoxygenases in the epithelium of cultured bovine cornea using an air interface model."
    Exp. Eye Res. 71: 57-67 (2000)
    more...

  • Alpert E., Gruzman A., Totary H., Kaiser N., Reich R., Sasson S.
    "A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid."
    Biochem. J. 362: 413-422 (2002)
    more...