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German Cancer Resarch CenterLOX-DB - LipOXygenases DataBase
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bt-5-lox

Gene name: none

Species: bovine (bos taurus)

Position of Oxygenation: 5

Substrate: arachidonic acid

Stereospecifity: S

Swissprot Entry: Q9BEG3

GenBank Entry: AJ306424

Modeled 3D-Structure: file in pdb-format (use Rasmol for viewing)

 - View with Webmol by Dirk Walther


left-click on the structure to rotate.
right-click on the structure to change properties.


Sequence: (430 Residues, 50.0 kDa - Values relating to this fragment)

MPSYTVTVAT GSQWFAGTDD YIYLSLVGSA GCSEKHLLDK PFYNDFERGA VDSYDVTVDE ELGDIQLIKI EKRKYWFHDD WYLKYITVKT PCGDYIEFPC YRWISGEGEI VLRDGQAKLA CDDQIHVLKQ HRRKELETRQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL NYSKAMENLF INRFMHMFQS SWSDFADFEK IFVRISNTIS ERVMNHWQED RMFGYQFLNG CNPVMIQRCL KLPDNLPVTT EMVECSLERQ LTLEQEIEQG NIFIVDFKLL DGIDANKTDP CTLQFLAAPI CLLYKNLANK IVPIAIQLNQ VPGEENPIFL PSDAKYDWLL AKIWVRSSDF HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPIFKLLVAH VRFTIAINTK AREQLICEYG LFDKANATGG


Literature:

  • Liminga M., Oliw E.H.
    "Studies of lipoxygenases in the epithelium of cultured bovine cornea using an air interface model."
    Exp. Eye Res. 71: 57-67 (2000)
    more...

  • Nally J.E., Bunton D.C., Martin D., Thomson N.C.
    "The role of cyclooxygenase and 5-lipoxygenase metabolites in potentiated endothelin-1-evoked contractions in bovine bronchi."
    Pulm. Pharmacol. 9: 211-217 (1996)
    more...

  • Sala A., Testa T., Folco G.
    "Leukotriene A4, and not leukotriene B4, is the main 5-lipoxygenase metabolite released by bovine leukocytes."
    FEBS Lett. 388: 94-98 (1996)
    more...