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German Cancer Resarch CenterLOX-DB - LipOXygenases DataBase
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LOX-DB - Literature related to rn-5-lox

Found 28 entries:

  • Deng YM , Xie QM , Zhang SJ , Chen JQ , Yang QH , Bian RL
    "Changes of 5-lipoxygenase pathway and proinflammatory mediators in cerebral cortex and lung tissue of sensitized rats."
    Acta Pharmacol Sin 26: 353-8 (2005)

  • Chen X , Wang S , Wu N , Sood S , Wang P , Jin Z , Beer DG , Giordano TJ , Lin Y , Shih WC , Lubet RA , Yang CS
    "Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis."
    Clin Cancer Res 10: 6703-9 (2004)

  • Graupera M., Garcia-Pagan J.C., Titos E., Claria J., Massaguer A., Bosch J., Rodes J.
    "5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes."
    Gastroenterology 122: 387-393 (2002)

  • Easton A , Abbott N
    "Bradykinin increases permeability by calcium and 5-lipoxygenase in the ECV304/C6 cell culture model of the blood-brain barrier."
    Brain Res 953: 157 (2002)

  • Burkert E , Radmark O , Steinhilber D , Werz O
    "Monocyte-derived soluble protein confers 5-lipoxygenase activity Ca2+-dependent."
    Biochem Biophys Res Commun 295: 985-991 (2002)

  • Escoubet-Lozach L , M'Rini C , Rey A , Beraud M , Lepert JC , Courtade M , Frisach MF , Pipy B
    "Increased expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in rat peritoneal macrophages during ovalbumin-induced sensitization."
    Clin Exp Allergy 31: 1094-1104 (2001)

  • Escoubet-Lozach L, M'Rini CF, Rey A, Beraud M, Lepert JC, Bernard J, Mathieu JR, Pipy B
    "Contrasting effect of interleukin-4 on the expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in peritoneal macrophages from control and ovalbumin-sensitized rats."
    Eur Cytokine Netw 12: 162-171 (2001)

  • Qu T, Uz T, Manev H
    "Inflammatory 5-LOX mRNA and protein are increased in brain of aging rats."
    Neurobiol Aging 21: 647-652 (2000)

  • Coffey MJ, Phare SM, Peters-Golden M
    "Prolonged exposure to lipopolysaccharide inhibits macrophage 5-lipoxygenase metabolism via induction of nitric oxide synthesis."
    J Immunol 165: 3592-3598 (2000)

  • Manev H, Uz T, Sugaya K, Qu T
    "Putative role of neuronal 5-lipoxygenase in an aging brain."
    FASEB J 14: 1464-1469 (2000)

  • Manev H, Uz T
    "Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression."
    Ann N Y Acad Sci 890: 183-190 (1999)

  • Ozeki Y, Nagamura Y, Ito H, Unemi F, Kimura Y, Igawa T, Kambayashi J, Takahashi Y, Yoshimoto T
    "An anti-platelet agent, OPC-29030, inhibits translocation of 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid production in human platelets."
    Br J Pharmacol 128: 1699-1704 (1999)

  • Uz T, Dwivedi Y, Savani PD, Impagnatiello F, Pandey G, Manev H
    "Glucocorticoids stimulate inflammatory 5-lipoxygenase gene expression and protein translocation in the brain."
    J Neurochem 73: 693-699 (1999)

  • Phare SM , Peters-Golden M , Coffey MJ
    "Alveolar lining fluid regulates mononuclear phagocyte 5-lipoxygenase metabolism."
    Eur Respir J 12: 1141-1146 (1998)

  • Uz T , Pesold C , Longone P , Manev H
    "Aging-associated up-regulation of neuronal 5-lipoxygenase expression: putative role in neuronal vulnerability."
    FASEB J 12: 439-449 (1998)

  • Benz M., Werz O., Jacob R., Steinhilber D.
    "pH-dependent regulation of leukocyte 5-lipoxygenase activity in inflammatory exudates by albumin."
    Inflamm. Res. 46: 366-372 (1997)

  • Carty TJ, Sweeney FJ, Griffiths RJ, Eskra JD, Ernest MJ, Pillar JS, Cheng JD, Loose LD, Joseph PA, Pazoles PP, Moore PF, Nagahisa A, Murase S, Kadin SB
    "Tenidap inhibits 5-lipoxygenase product formation in vitro, but this activity is not observed in three animal models."
    Inflamm Res 46: 168-179 (1997)

  • Voelkel NF, Tuder RM, Wade K, Hoper M, Lepley RA, Goulet JL, Koller BH, Fitzpatrick F
    "Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats."
    J Clin Invest 97: 2491-2498 (1996)

  • Lammers CH, Schweitzer P, Facchinetti P, Arrang JM, Madamba SG, Siggins GR, Piomelli D
    "Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling."
    J Neurochem 66: 147-152 (1996)

  • Bhatia PA, Brooks CD, Basha A, Ratajczyk JD, Gunn BP, Bouska JB, Lanni C, Young PR, Bell RL, Carter GW
    "5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones."
    J Med Chem 39: 3938-3950 (1996)

  • Westcott JY, Wenzel SE, Dreskin SC
    "Arachidonate-induced eicosanoid synthesis in RBL-2H3 cells: stimulation with antigen or A23187 induces prolonged activation of 5-lipoxygenase."
    Biochim Biophys Acta 1303: 74-81 (1996)

  • Brock TG , Paine R 3rd , Peters-Golden M
    "Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells."
    J Biol Chem 269: 22059-22066 (1994)

  • Minor W., Steczko J., Bolin J.T., Otwinowski Z., Axelrod B.
    "Crystallographic determination of the active site iron and its ligands in soybean lipoxygenase L-1."
    Biochemistry 32: 6320-6323 (1993)

  • Grimes D, Sturm RJ, Marinari LR, Carlson RP, Berkenkopf JW, Musser JH, Kreft AF, Weichman BM
    "WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity."
    Eur J Pharmacol 236: 217-228 (1993)

  • Takahashi H , Abe M , Hashimoto S , Takayama K , Miyazaki M
    "In vivo effect of lipopolysaccharide on alveolar and peritoneal macrophages of rats: superoxide anion generation and 5-lipoxygenase metabolism of arachidonic acid."
    Am J Respir Cell Mol Biol 8: 291-298 (1993)

  • Carter GW, Young PR, Albert DH, Bouska J, Dyer R, Bell RL, Summers JB, Brooks DW
    "5-lipoxygenase inhibitory activity of zileuton."
    J Pharmacol Exp Ther 256: 929-937 (1991)

  • Balcarek J.M., Theisen T.W., Cook M.N., Varrichio A., Hwang S.-M., Strohsacker M.W., Crooke S.T.
    "Isolation and characterization of a cDNA clone encoding rat 5-lipoxygenase."
    J. Biol. Chem. 263: 13937-13941 (1988)

  • Jung G, Yang DC, Nakao A
    "Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenase."
    Biochem Biophys Res Commun 130: 559-566 (1985)