Deutsches Krebsforschungszentrum 
German Cancer Resarch CenterLOX-DB - LipOXygenases DataBase
Lipoxygenases...
What are Lipoxygenases?
Lipoxygenases and
cancer research
Database...
Search
Display all entries
Alignments
Sequence Comparison
Blast Search
Search Literature
Search Literature (adv.)
Misc...
Image Gallery
Links
Forum
Contact
Guestbook
Home

LOX-DB - Literature related to oc-15-lox


Found 50 entries:

  • Vijayvergiya C, De Angelis D, Walther M, Kuhn H, Duvoisin RM, Smith DH, Wiedmann M
    "High-Level Expression of Rabbit 15-Lipoxygenase Induces Collapse of the Mitochondrial pH Gradient in Cell Culture."
    Biochemistry 43: 15296-15302 (2004)
    more...

  • Hammel M , Walther M , Prassl R , Kuhn H
    "Structural flexibility of the N-terminal beta-barrel domain of 15-lipoxygenase-1 probed by small angle X-ray scattering. Functional consequences for activity regulation and membrane binding."
    J Mol Biol 343: 917-929 (2004)
    more...

  • Walther M., Anton M., Wiedmann M., Fletterick R., Kuhn H.
    "The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding."
    J. Biol. Chem. 277: 27360-27366 (2002)
    more...

  • Kozak K.R., Gupta R.A., Moody J.S., Ji C., Boeglin W.E., DuBois R.N., Brash A.R., Marnett L.J.
    "15-lipoxygenase metabolism of 2-arachidonylglycerol: Generation of a PPARalpha agonist."
    J. Biol. Chem. 277: 23278-23286 (2002)
    more...

  • Schewe T
    "15-lipoxygenase-1: a prooxidant enzyme."
    Biol Chem 383: 365-374 (2002)
    more...

  • Noguchi N , Yamashita H , Hamahara J , Nakamura A , Kuhn H , Niki E
    "The specificity of lipoxygenase-catalyzed lipid peroxidation and the effects of radical-scavenging antioxidants."
    Biol Chem 383: 619-626 (2002)
    more...

  • Walther M., Ivanov I., Myagkova G., Kuhn H.
    "Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis."
    Chem. Biol. 8: 779-790 (2001)
    more...

  • Schewe T., Sadik C., Klotz L.O., Yoshimoto T., Kuhn H., Sies H.
    "Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase."
    Biol. Chem. 382: 1687-1696 (2001)
    more...

  • Grullich C, Duvoisin RM, Wiedmann M, van Leyen K
    "Inhibition of 15-lipoxygenase leads to delayed organelle degradation in the reticulocyte."
    FEBS Lett 489: 51-54 (2001)
    more...

  • Heydeck D, Upston JM, Viita H, Yla-Herttuala S, Stocker R
    "Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions."
    J Lipid Res 42: 1082-1088 (2001)
    more...

  • Tornhamre S., Elmqvist A., Lindgren J.A.
    "15-Lipoxygenation of leukotriene A(4). Studies Of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation."
    Biochim. Biophys. Acta 1484: 298-306 (2000)
    more...

  • Borngräber S., Browner M., Gillmor S., Gerth C., Anton M., Fletterick R., Kuhn H.
    "Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity."
    J. Biol. Chem. 274: 37345-37350 (1999)
    more...

  • Kuhn H, Heydeck D, Brinckman R, Trebus F
    "Regulation of cellular 15-lipoxygenase activity on pretranslational, translational, and posttranslational levels."
    Lipids 34: S273-279 (1999)
    more...

  • Walther M, Holzhutter HG, Kuban RJ, Wiesner R, Rathmann J, Kuhn H
    "The inhibition of mammalian 15-lipoxygenases by the anti-inflammatory drug ebselen: dual-type mechanism involving covalent linkage and alteration of the iron ligand sphere."
    Mol Pharmacol 56: 196-203 (1999)
    more...

  • Juranek I , Suzuki H , Yamamoto S
    "Affinities of various mammalian arachidonate lipoxygenases and cyclooxygenases for molecular oxygen as substrate."
    Biochim Biophys Acta 1436: 509-518 (1999)
    more...

  • Thiele BJ, Berger M, Huth A, Reimann I, Schwarz K, Thiele H
    "Tissue-specific translational regulation of alternative rabbit 15-lipoxygenase mRNAs differing in their 3'-untranslated regions."
    Nucleic Acids Res 27: 1828-1836 (1999)
    more...

  • Thiele BJ, Berger M, Schwarz K, Borngraber S, Kuhn H, Ostareck-Lederer A, Thiele H
    "Expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits."
    Adv Exp Med Biol 447: 45-61 (1999)
    more...

  • Yamashita H, Nakamura A, Noguchi N, Niki E, Kuhn H
    "Oxidation of low density lipoprotein and plasma by 15-lipoxygenase and free radicals."
    FEBS Lett 445: 287-290 (1999)
    more...

  • Berger M., Schwarz K., Thiele H., Reimann I., Huth A., Borngraber S., Kuhn H., Thiele B.J.
    "Simultaneous expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits."
    J. Mol. Biol. 278: 935-948 (1998)
    more...

  • Schwarz K, Borngraber S, Anton M, Kuhn H
    "Probing the substrate alignment at the active site of 15-lipoxygenases by targeted substrate modification and site-directed mutagenesis. Evidence for an inverse substrate orientation."
    Biochemistry 37: 15327-15335 (1998)
    more...

  • Ivanov I, Schwarz K, Holzhutter HG, Myagkova G, Kuhn H
    "Omega-oxidation impairs oxidizability of polyenoic fatty acids by 15-lipoxygenases: consequences for substrate orientation at the active site."
    Biochem J 336: 345-352 (1998)
    more...

  • Belkner J, Stender H, Kuhn H
    "The rabbit 15-lipoxygenase preferentially oxygenates LDL cholesterol esters, and this reaction does not require vitamin E."
    J Biol Chem 273: 23225-23232 (1998)
    more...

  • Borngraber S, Grabenhorst E, Anton M, Conradt H, Kuhn H
    "Intra- and extracellular expression of rabbit reticulocyte 15-lipoxygenase in the Baculovirus/insect cell system."
    Protein Expr Purif 14: 237-246 (1998)
    more...

  • Brinckmann R, Schnurr K, Heydeck D, Rosenbach T, Kolde G, Kuhn H
    "Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme."
    Blood 91: 64-74 (1998)
    more...

  • Kuban RJ, Wiesner R, Rathman J, Veldink G, Nolting H, Sole VA, Kuhn H
    "The iron ligand sphere geometry of mammalian 15-lipoxygenases."
    Biochem J 332: 237-242 (1998)
    more...

  • Gillmor S.A., Villasenor A., Fletterick R., Sigal E., Browner M.F.
    "The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity."
    Nat. Struct. Biol. 4: 1003-1009 (1997)
    more...

  • O'donnell VB, Kuhn H
    "Co-oxidation of NADH and NADPH by a mammalian 15-lipoxygenase: inhibition of lipoxygenase activity at near-physiological NADH concentrations."
    Biochem J 327: 203-208 (1997)
    more...

  • Ek BA , Cistola DP , Hamilton JA , Kaduce TL , Spector AA
    "Fatty acid binding proteins reduce 15-lipoxygenase-induced oxygenation of linoleic acid and arachidonic acid."
    Biochim Biophys Acta 1346: 75-85 (1997)
    more...

  • Holzhutter HG, Wiesner R, Rathmann J, Stosser R, Kuhn H
    "A kinetic model for the interaction of nitric oxide with a mammalian lipoxygenase."
    Eur J Biochem 245: 608-616 (1997)
    more...

  • Borngraber S., Kuban R.J., Anton M., Kuhn H.
    "Phenylalanine 353 is a primary determinant for the positional specificity of mammalian 15-lipoxygenases."
    J. Mol. Biol. 264: 1145-1153 (1996)
    more...

  • Schnurr K , Belkner J , Ursini F , Schewe T , Kuhn H
    "The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products."
    J Biol Chem 271: 4653-4658 (1996)
    more...

  • Schnurr K, Hellwing M, Seidemann B, Jungblut P, Kuhn H, Rapoport SM, Schewe T
    "Oxygenation of biomembranes by mammalian lipoxygenases: the role of ubiquinone."
    Free Radic Biol Med 20: 11-21 (1996)
    more...

  • Shen J, Herderick E, Cornhill JF, Zsigmond E, Kim HS, Kuhn H, Guevara NV, Chan L
    "Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development."
    J Clin Invest 98: 2201-2208 (1996)
    more...

  • O'Prey J, Harrison PR
    "Tissue-specific regulation of the rabbit 15-lipoxygenase gene in erythroid cells by a transcriptional silencer."
    Nucleic Acids Res 23: 3664-3672 (1995)
    more...

  • Kuhn H., Belkner J., Suzuki H., Yamamoto S.
    "Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities."
    J. Lipid Res. 35: 1749-1759 (1994)
    more...

  • Kuhn H, Belkner J, Zaiss S, Fahrenklemper T, Wohlfeil S
    "Involvement of 15-lipoxygenase in early stages of atherogenesis."
    J Exp Med 179: 1903-1911 (1994)
    more...

  • Watson A, Doherty FJ
    "Calcium promotes membrane association of reticulocyte 15-lipoxygenase."
    Biochem J 298: 377-383 (1994)
    more...

  • Bell RL, Brooks DW, Young PR, Lanni C, Stewart AO, Bouska J, Malo PE, Carter GW
    "A-78773: a selective, potent 5-lipoxygenase inhibitor."
    J Lipid Mediat 6: 259-264 (1993)
    more...

  • Kuhn H, Thiele BJ, Ostareck-Lederer A, Stender H, Suzuki H, Yoshimoto T, Yamamoto S
    "Bacterial expression, purification and partial characterization of recombinant rabbit reticulocyte 15-lipoxygenase."
    Biochim Biophys Acta 1168: 73-78 (1993)
    more...

  • Kuhn H, Heydeck D, Sprecher H
    "On the mechanistic reasons for the dual positional specificity of the reticulocyte lipoxygenase."
    Biochim Biophys Acta 1081: 129-134 (1991)
    more...

  • Simon TC, Makheja AN, Bailey JM
    "Relationship of vascular 15-lipoxygenase induction to atherosclerotic plaque formation in rabbits."
    Prostaglandins Leukot Essent Fatty Acids 41: 273-278 (1990)
    more...

  • Kuhn H , Belkner J , Wiesner R
    "Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes."
    Eur J Biochem 191: 221-227 (1990)
    more...

  • Kuhn H, Belkner J, Wiesner R, Brash AR
    "Oxygenation of biological membranes by the pure reticulocyte lipoxygenase."
    J Biol Chem 265: 18351-18361 (1990)
    more...

  • Kuhn H, Brash AR
    "Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells."
    J Biol Chem 265: 1454-1458 (1990)
    more...

  • Thiele BJ, Fleming J, Chester J, O'Prey J, Prehn S, Janetzki S, Rapoport SM, Harrison PR
    "Structure of the mRNA and of the gene coding for the rabbit erythroid 15-lipoxygenase."
    Biomed Biochim Acta 49: S17-24 (1990)
    more...

  • Fleming J., Thiele B.J., Chester J., O'Prey J., Janetzki S., Aitken A., Anton I.A., Rapoport S.M., Harrison P.R.
    "The complete sequence of the rabbit erythroid cell-specific 15-lipoxygenase mRNA: comparison of the predicted amino acid sequence of the erythrocyte lipoxygenase with other lipoxygenases."
    Gene 79: 181-188 (1989)
    more...

  • O'Prey J., Chester J., Thiele B.J., Janetzki S., Prehn S., Fleming J., Harrison P.R.
    "The promoter structure and complete sequence of the gene encoding the rabbit erythroid cell-specific 15-lipoxygenase."
    Gene 84: 493-499 (1989)
    more...

  • Thiele BJ, Fleming J, Kasturi K, O'Prey J, Black E, Chester J, Rapoport SM, Harrison PR
    "Cloning of a rabbit erythroid-cell-specific lipoxygenase mRNA."
    Gene 57: 111-119 (1987)
    more...

  • Jung G, Yang DC, Nakao A
    "Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenase."
    Biochem Biophys Res Commun 130: 559-566 (1985)
    more...

  • Vanderhoek JY, Bryant RW, Bailey JM
    "Regulation of leukocyte and platelet lipoxygenases by hydroxyeicosanoids."
    Biochem Pharmacol 31: 3463-3467 (1982)
    more...