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LOX-DB - Literature related to oc-15-lox

Found 50 entries:

  • Vijayvergiya C, De Angelis D, Walther M, Kuhn H, Duvoisin RM, Smith DH, Wiedmann M
    "High-Level Expression of Rabbit 15-Lipoxygenase Induces Collapse of the Mitochondrial pH Gradient in Cell Culture."
    Biochemistry 43: 15296-15302 (2004)

  • Hammel M , Walther M , Prassl R , Kuhn H
    "Structural flexibility of the N-terminal beta-barrel domain of 15-lipoxygenase-1 probed by small angle X-ray scattering. Functional consequences for activity regulation and membrane binding."
    J Mol Biol 343: 917-929 (2004)

  • Walther M., Anton M., Wiedmann M., Fletterick R., Kuhn H.
    "The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding."
    J. Biol. Chem. 277: 27360-27366 (2002)

  • Kozak K.R., Gupta R.A., Moody J.S., Ji C., Boeglin W.E., DuBois R.N., Brash A.R., Marnett L.J.
    "15-lipoxygenase metabolism of 2-arachidonylglycerol: Generation of a PPARalpha agonist."
    J. Biol. Chem. 277: 23278-23286 (2002)

  • Schewe T
    "15-lipoxygenase-1: a prooxidant enzyme."
    Biol Chem 383: 365-374 (2002)

  • Noguchi N , Yamashita H , Hamahara J , Nakamura A , Kuhn H , Niki E
    "The specificity of lipoxygenase-catalyzed lipid peroxidation and the effects of radical-scavenging antioxidants."
    Biol Chem 383: 619-626 (2002)

  • Walther M., Ivanov I., Myagkova G., Kuhn H.
    "Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis."
    Chem. Biol. 8: 779-790 (2001)

  • Schewe T., Sadik C., Klotz L.O., Yoshimoto T., Kuhn H., Sies H.
    "Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase."
    Biol. Chem. 382: 1687-1696 (2001)

  • Grullich C, Duvoisin RM, Wiedmann M, van Leyen K
    "Inhibition of 15-lipoxygenase leads to delayed organelle degradation in the reticulocyte."
    FEBS Lett 489: 51-54 (2001)

  • Heydeck D, Upston JM, Viita H, Yla-Herttuala S, Stocker R
    "Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions."
    J Lipid Res 42: 1082-1088 (2001)

  • Tornhamre S., Elmqvist A., Lindgren J.A.
    "15-Lipoxygenation of leukotriene A(4). Studies Of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation."
    Biochim. Biophys. Acta 1484: 298-306 (2000)

  • Borngräber S., Browner M., Gillmor S., Gerth C., Anton M., Fletterick R., Kuhn H.
    "Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity."
    J. Biol. Chem. 274: 37345-37350 (1999)

  • Kuhn H, Heydeck D, Brinckman R, Trebus F
    "Regulation of cellular 15-lipoxygenase activity on pretranslational, translational, and posttranslational levels."
    Lipids 34: S273-279 (1999)

  • Walther M, Holzhutter HG, Kuban RJ, Wiesner R, Rathmann J, Kuhn H
    "The inhibition of mammalian 15-lipoxygenases by the anti-inflammatory drug ebselen: dual-type mechanism involving covalent linkage and alteration of the iron ligand sphere."
    Mol Pharmacol 56: 196-203 (1999)

  • Juranek I , Suzuki H , Yamamoto S
    "Affinities of various mammalian arachidonate lipoxygenases and cyclooxygenases for molecular oxygen as substrate."
    Biochim Biophys Acta 1436: 509-518 (1999)

  • Thiele BJ, Berger M, Huth A, Reimann I, Schwarz K, Thiele H
    "Tissue-specific translational regulation of alternative rabbit 15-lipoxygenase mRNAs differing in their 3'-untranslated regions."
    Nucleic Acids Res 27: 1828-1836 (1999)

  • Thiele BJ, Berger M, Schwarz K, Borngraber S, Kuhn H, Ostareck-Lederer A, Thiele H
    "Expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits."
    Adv Exp Med Biol 447: 45-61 (1999)

  • Yamashita H, Nakamura A, Noguchi N, Niki E, Kuhn H
    "Oxidation of low density lipoprotein and plasma by 15-lipoxygenase and free radicals."
    FEBS Lett 445: 287-290 (1999)

  • Berger M., Schwarz K., Thiele H., Reimann I., Huth A., Borngraber S., Kuhn H., Thiele B.J.
    "Simultaneous expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits."
    J. Mol. Biol. 278: 935-948 (1998)

  • Schwarz K, Borngraber S, Anton M, Kuhn H
    "Probing the substrate alignment at the active site of 15-lipoxygenases by targeted substrate modification and site-directed mutagenesis. Evidence for an inverse substrate orientation."
    Biochemistry 37: 15327-15335 (1998)

  • Ivanov I, Schwarz K, Holzhutter HG, Myagkova G, Kuhn H
    "Omega-oxidation impairs oxidizability of polyenoic fatty acids by 15-lipoxygenases: consequences for substrate orientation at the active site."
    Biochem J 336: 345-352 (1998)

  • Belkner J, Stender H, Kuhn H
    "The rabbit 15-lipoxygenase preferentially oxygenates LDL cholesterol esters, and this reaction does not require vitamin E."
    J Biol Chem 273: 23225-23232 (1998)

  • Borngraber S, Grabenhorst E, Anton M, Conradt H, Kuhn H
    "Intra- and extracellular expression of rabbit reticulocyte 15-lipoxygenase in the Baculovirus/insect cell system."
    Protein Expr Purif 14: 237-246 (1998)

  • Brinckmann R, Schnurr K, Heydeck D, Rosenbach T, Kolde G, Kuhn H
    "Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme."
    Blood 91: 64-74 (1998)

  • Kuban RJ, Wiesner R, Rathman J, Veldink G, Nolting H, Sole VA, Kuhn H
    "The iron ligand sphere geometry of mammalian 15-lipoxygenases."
    Biochem J 332: 237-242 (1998)

  • Gillmor S.A., Villasenor A., Fletterick R., Sigal E., Browner M.F.
    "The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity."
    Nat. Struct. Biol. 4: 1003-1009 (1997)

  • O'donnell VB, Kuhn H
    "Co-oxidation of NADH and NADPH by a mammalian 15-lipoxygenase: inhibition of lipoxygenase activity at near-physiological NADH concentrations."
    Biochem J 327: 203-208 (1997)

  • Ek BA , Cistola DP , Hamilton JA , Kaduce TL , Spector AA
    "Fatty acid binding proteins reduce 15-lipoxygenase-induced oxygenation of linoleic acid and arachidonic acid."
    Biochim Biophys Acta 1346: 75-85 (1997)

  • Holzhutter HG, Wiesner R, Rathmann J, Stosser R, Kuhn H
    "A kinetic model for the interaction of nitric oxide with a mammalian lipoxygenase."
    Eur J Biochem 245: 608-616 (1997)

  • Borngraber S., Kuban R.J., Anton M., Kuhn H.
    "Phenylalanine 353 is a primary determinant for the positional specificity of mammalian 15-lipoxygenases."
    J. Mol. Biol. 264: 1145-1153 (1996)

  • Schnurr K , Belkner J , Ursini F , Schewe T , Kuhn H
    "The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products."
    J Biol Chem 271: 4653-4658 (1996)

  • Schnurr K, Hellwing M, Seidemann B, Jungblut P, Kuhn H, Rapoport SM, Schewe T
    "Oxygenation of biomembranes by mammalian lipoxygenases: the role of ubiquinone."
    Free Radic Biol Med 20: 11-21 (1996)

  • Shen J, Herderick E, Cornhill JF, Zsigmond E, Kim HS, Kuhn H, Guevara NV, Chan L
    "Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development."
    J Clin Invest 98: 2201-2208 (1996)

  • O'Prey J, Harrison PR
    "Tissue-specific regulation of the rabbit 15-lipoxygenase gene in erythroid cells by a transcriptional silencer."
    Nucleic Acids Res 23: 3664-3672 (1995)

  • Kuhn H., Belkner J., Suzuki H., Yamamoto S.
    "Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities."
    J. Lipid Res. 35: 1749-1759 (1994)

  • Kuhn H, Belkner J, Zaiss S, Fahrenklemper T, Wohlfeil S
    "Involvement of 15-lipoxygenase in early stages of atherogenesis."
    J Exp Med 179: 1903-1911 (1994)

  • Watson A, Doherty FJ
    "Calcium promotes membrane association of reticulocyte 15-lipoxygenase."
    Biochem J 298: 377-383 (1994)

  • Bell RL, Brooks DW, Young PR, Lanni C, Stewart AO, Bouska J, Malo PE, Carter GW
    "A-78773: a selective, potent 5-lipoxygenase inhibitor."
    J Lipid Mediat 6: 259-264 (1993)

  • Kuhn H, Thiele BJ, Ostareck-Lederer A, Stender H, Suzuki H, Yoshimoto T, Yamamoto S
    "Bacterial expression, purification and partial characterization of recombinant rabbit reticulocyte 15-lipoxygenase."
    Biochim Biophys Acta 1168: 73-78 (1993)

  • Kuhn H, Heydeck D, Sprecher H
    "On the mechanistic reasons for the dual positional specificity of the reticulocyte lipoxygenase."
    Biochim Biophys Acta 1081: 129-134 (1991)

  • Simon TC, Makheja AN, Bailey JM
    "Relationship of vascular 15-lipoxygenase induction to atherosclerotic plaque formation in rabbits."
    Prostaglandins Leukot Essent Fatty Acids 41: 273-278 (1990)

  • Kuhn H , Belkner J , Wiesner R
    "Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes."
    Eur J Biochem 191: 221-227 (1990)

  • Kuhn H, Belkner J, Wiesner R, Brash AR
    "Oxygenation of biological membranes by the pure reticulocyte lipoxygenase."
    J Biol Chem 265: 18351-18361 (1990)

  • Kuhn H, Brash AR
    "Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells."
    J Biol Chem 265: 1454-1458 (1990)

  • Thiele BJ, Fleming J, Chester J, O'Prey J, Prehn S, Janetzki S, Rapoport SM, Harrison PR
    "Structure of the mRNA and of the gene coding for the rabbit erythroid 15-lipoxygenase."
    Biomed Biochim Acta 49: S17-24 (1990)

  • Fleming J., Thiele B.J., Chester J., O'Prey J., Janetzki S., Aitken A., Anton I.A., Rapoport S.M., Harrison P.R.
    "The complete sequence of the rabbit erythroid cell-specific 15-lipoxygenase mRNA: comparison of the predicted amino acid sequence of the erythrocyte lipoxygenase with other lipoxygenases."
    Gene 79: 181-188 (1989)

  • O'Prey J., Chester J., Thiele B.J., Janetzki S., Prehn S., Fleming J., Harrison P.R.
    "The promoter structure and complete sequence of the gene encoding the rabbit erythroid cell-specific 15-lipoxygenase."
    Gene 84: 493-499 (1989)

  • Thiele BJ, Fleming J, Kasturi K, O'Prey J, Black E, Chester J, Rapoport SM, Harrison PR
    "Cloning of a rabbit erythroid-cell-specific lipoxygenase mRNA."
    Gene 57: 111-119 (1987)

  • Jung G, Yang DC, Nakao A
    "Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenase."
    Biochem Biophys Res Commun 130: 559-566 (1985)

  • Vanderhoek JY, Bryant RW, Bailey JM
    "Regulation of leukocyte and platelet lipoxygenases by hydroxyeicosanoids."
    Biochem Pharmacol 31: 3463-3467 (1982)