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German Cancer Resarch CenterLOX-DB - LipOXygenases DataBase
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LOX-DB - Literature related to m-l12-lox

Found 25 entries:

  • Anning PB, Coles B, Bermudez-Fajardo A, Martin PE, Levison BS, Hazen SL, Funk CD, Kuhn H, O'donnell VB
    "Elevated endothelial nitric oxide bioactivity and resistance to Angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice."
    Am J Pathol 166: 653-662 (2005)

  • Chen M , Yang ZD , Smith KM , Carter JD , Nadler JL
    "Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity."
    Diabetologia 0: (2005)

  • Kim YS, Xu ZG, Reddy MA, Li SL, Lanting L, Sharma K, Adler SG, Natarajan R
    "Novel interactions between TGF-{beta}1 actions and the 12/15-lipoxygenase pathway in mesangial cells."
    J Am Soc Nephrol 16: 352-62 (2005)

  • Gonzalez-Nunez D , Sole M , Natarajan R , Poch E
    "12-Lipoxygenase metabolism in mouse distal convoluted tubule cells."
    Kidney Int 67: 178-86 (2005)

  • Li SL, Dwarakanath RS, Cai Q, Lanting L, Natarajan R
    "Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs."
    J Lipid Res 46: 220-9 (2005)

  • Afek A, Zurgil N, Bar-Dayan Y, Polak-Charcon S, Goldberg I, Deutsch M, Kopolovich J, Keren G, Harats D, George J
    "Overexpression of 15-lipoxygenase in the vascular endothelium is associated with increased thymic apoptosis in LDL receptor-deficient mice."
    Pathobiology 71: 261-266 (2004)

  • Huo Y, Zhao L, Hyman MC, Shashkin P, Harry BL, Burcin T, Forlow SB, Stark MA, Smith DF, Clarke S, Srinivasan S, Hedrick CC, Pratico D, Witztum JL, Nadler JL, Funk CD, Ley K
    "Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice."
    Circulation 110: 2024-31 (2004)

  • Emerson MR, LeVine SM
    "Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase."
    Brain Res 1021: 140-5 (2004)

  • Kelavkar UP, Glasgow W, Olson SJ, Foster BA, Shappell SB
    "Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice."
    Neoplasia 6: 821-830 (2004)

  • Wen Y, Gu J, Peng X, Zhang G, Nadler J
    "Overexpression of 12-lipoxygenase and cardiac fibroblast hypertrophy."
    Trends Cardiovasc Med 13: 129-136 (2003)

  • Shappell SB , Olson SJ , Hannah SE , Manning S , Roberts RL , Masumori N , Jisaka M , Boeglin WE , Vader V , Dave DS , Shook MF , Thomas TZ , Funk CD , Brash AR , Matusik RJ
    "Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma."
    Cancer Res 63: 2256-2267 (2003)

  • Kawajiri H., Hsi L.C., Kamitani H., Ikawa H., Geller M., Ward T., Eling T.E., Glasgow W.C.
    "Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity."
    Arch. Biochem. Biophys. 398: 51-60 (2002)

  • Muller K, Siebert M, Heidt M, Marks F, Krieg P, Furstenberger G
    "Modulation of Epidermal Tumor Development Caused by Targeted Overexpression of Epidermis-type 12S-Lipoxygenase."
    Cancer Res. 62: 4610-4616 (2002)

  • Schewe T
    "15-lipoxygenase-1: a prooxidant enzyme."
    Biol Chem 383: 365-374 (2002)

  • George J., Afek A., Shaish A., Levkovitz H., Bloom N., Cyrus T., Zhao L., Funk C.D., Sigal E., Harats D.
    "12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice."
    Circulation 104: 1646-1650 (2001)

  • Buerger F., Krieg P., Marks F., Fuerstenberger G.
    "Positional- and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymes."
    Biochem. J. 348: 329-335 (2000)

  • Bleich D, Chen S, Zipser B, Sun D, Funk CD, Nadler JL
    "Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice."
    J Clin Invest 103: 1431-1436 (1999)

  • Secor WE, Powell MR, Morgan J, Wynn TA, Funk CD
    "Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni."
    Prostaglandins Other Lipid Mediat 56: 291-304 (1998)

  • Heydeck D, Thomas L, Schnurr K, Trebus F, Thierfelder WE, Ihle JN, Kuhn H
    "Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6."
    Blood 92: 2503-2510 (1998)

  • Sendobry SM, Cornicelli JA, Welch K, Grusby MJ, Daugherty A
    "Absence of T lymphocyte-derived cytokines fails to diminish macrophage 12/15-lipoxygenase expression in vivo."
    J Immunol 161: 1477-1482 (1998)

  • Scheidegger KJ, Butler S, Witztum JL
    "Angiotensin II increases macrophage-mediated modification of low density lipoprotein via a lipoxygenase-dependent pathway."
    J Biol Chem 272: 21609-21615 (1997)

  • Sun D., Funk C.D.
    "Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein."
    J. Biol. Chem. 271: 24055-24062 (1996)

  • Freire-Moar J., Alavi-Nassab A., Ng M., Mulkins M., Sigal E.
    "Cloning and characterization of a murine macrophage lipoxygenase."
    Biochim. Biophys. Acta 1254: 112-116 (1995)

  • Chen X.-S., Kurre U., Jenkins N.A., Copeland N.G., Funk C.D.
    "cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases."
    J. Biol. Chem. 269: 13979-13987 (1994)

  • Chang WC, Ning CC, Lin MT, Huang JD
    "Epidermal growth factor enhances a microsomal 12-lipoxygenase activity in A431 cells."
    J Biol Chem 267: 3657-3666 (1992)