Deutsches Krebsforschungszentrum 
German Cancer Resarch CenterLOX-DB - LipOXygenases DataBase
What are Lipoxygenases?
Lipoxygenases and
cancer research
Display all entries
Sequence Comparison
Blast Search
Search Literature
Search Literature (adv.)
Image Gallery

LOX-DB - Literature related to m-5-lox

Found 24 entries:

  • Benjamim CF, Canetti C, Cunha FQ, Kunkel SL, Peters-Golden M
    "Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis."
    J Immunol 174: 1616-20 (2005)

  • Emerson MR, LeVine SM
    "Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase."
    Brain Res 1021: 140-5 (2004)

  • Yildirim E, Zhang Z, Uz T, Chen C, Manev R, Manev H
    "Valproate administration to mice increases histone acetylation and 5-lipoxygenase content in the hippocampus."
    Neurosci Lett 345: 141-143 (2003)

  • Mehrabian M , Allayee H
    "5-lipoxygenase and atherosclerosis."
    Curr Opin Lipidol 14: 447-457 (2003)

  • Segal B.H., Kuhns D.B., Ding L., Gallin J.I., Holland S.M.
    "Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation."
    J. Leukoc. Biol. 71: 410-416 (2002)

  • Kawajiri H., Hsi L.C., Kamitani H., Ikawa H., Geller M., Ward T., Eling T.E., Glasgow W.C.
    "Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity."
    Arch. Biochem. Biophys. 398: 51-60 (2002)

  • Uz T , Dimitrijevic N , Tueting P , Manev H
    "5-lipoxygenase (5LOX)-deficient mice express reduced anxiety-like behavior."
    Restor Neurol Neurosci 20: 15-20 (2002)

  • Mehrabian M, Allayee H, Wong J, Shih W, Wang XP, Shaposhnik Z, Funk CD, Lusis AJ
    "Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice."
    Circ Res 91: 120-126 (2002)

  • Silverman ES, Le L, Baron RM, Hallock A, Hjoberg J, Shikanai T, Storm van's Gravesande K, Auron PE, Lu W
    "Cloning and functional analysis of the mouse 5-lipoxygenase promoter."
    Am J Respir Cell Mol Biol 26: 475-483 (2002)

  • Chen X.S., Funk C.D.
    "The N-terminal 'beta-barrel' domain of 5-lipoxygenase is essential for nuclear membrane translocation."
    J. Biol. Chem. 276: 811-818 (2001)

  • Heidt M., Fuerstenberger G., Vogel S., Marks F., Krieg P.
    "Diversity of mouse lipoxygenases: identification of a subfamily of epidermal isozymes exhibiting a differentiation-dependent mRNA expression pattern."
    Lipids 35: 701-707 (2000)

  • Chu SJ , Tang LO , Watney E , Chi EY , Henderson WR Jr
    "In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade."
    J Immunol 165: 4640-4648 (2000)

  • Funk CD, Chen XS
    "5-Lipoxygenase and leukotrienes. Transgenic mouse and nuclear targeting studies."
    Am J Respir Crit Care Med 161: S120-4 (2000)

  • Coffey MJ, Phare SM, Peters-Golden M, Huffnagle GB
    "Regulation of 5-lipoxygenase metabolism in mononuclear phagocytes by CD4 T lymphocytes."
    Exp Lung Res 25: 617-629 (1999)

  • Secor WE, Powell MR, Morgan J, Wynn TA, Funk CD
    "Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni."
    Prostaglandins Other Lipid Mediat 56: 291-304 (1998)

  • Sun D., Funk C.D.
    "Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein."
    J. Biol. Chem. 271: 24055-24062 (1996)

  • Muller K, Huang HS, Wiegrebe W
    "Antipsoriatic anthrones with modulated redox properties. 3. 10-thio-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of keratinocyte growth, 5-lipoxygenase, and the formation of 12(S)-HETE in mouse epidermis."
    J Med Chem 39: 3132-3138 (1996)

  • Chen X.-S., Naumann T.A., Kurre U., Jenkins N.A., Copeland N.G., Funk C.D.
    "cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase."
    J. Biol. Chem. 270: 17993-17999 (1995)

  • Funk CD, Chen XS, Kurre U, Griffis G
    "Leukotriene-deficient mice generated by targeted disruption of the 5-lipoxygenase gene."
    Adv Prostaglandin Thromboxane Leukot Res 23: 145-150 (1995)

  • Chen XS, Sheller JR, Johnson EN, Funk CD
    "Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene."
    Nature 372: 179-182 (1994)

  • Goulet JL, Snouwaert JN, Latour AM, Coffman TM, Koller BH
    "Altered inflammatory responses in leukotriene-deficient mice."
    Proc Natl Acad Sci U S A 91: 12852-12856 (1994)

  • Jiang H, Yamamoto S, Kato R
    "Inhibition of two-stage skin carcinogenesis as well as complete skin carcinogenesis by oral administration of TMK688, a potent lipoxygenase inhibitor."
    Carcinogenesis 15: 807-812 (1994)

  • Grimes D, Sturm RJ, Marinari LR, Carlson RP, Berkenkopf JW, Musser JH, Kreft AF, Weichman BM
    "WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity."
    Eur J Pharmacol 236: 217-228 (1993)

  • Yamamoto S, Aizu E, Jiang H, Nakadate T, Kiyoto I, Wang JC, Kato R
    "The potent anti-tumor-promoting agent isoliquiritigenin."
    Carcinogenesis 12: 317-323 (1991)