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LOX-DB - Literature related to h-p12-lox


Found 85 entries:

  • Coffey MJ, Coles B, Locke M, Bermudez-Fajardo A, Williams PC, Jarvis GE, O'donnell VB
    "Interactions of 12-lipoxygenase with phospholipase A2 isoforms following platelet activation through the glycoprotein VI collagen receptor."
    FEBS Lett 576: 165-8 (2004)
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  • Goodman JE, Bowman ED, Chanock SJ, Alberg AJ, Harris CC
    "Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk."
    Carcinogenesis 25: 2467-2472 (2004)
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  • Segraves EN , Holman TR
    "Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase."
    Biochemistry 42: 5236-5243 (2003)
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  • Jiang WG, Douglas-Jones A, Mansel RE
    "Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer."
    Prostaglandins Leukot Essent Fatty Acids 69: 275-281 (2003)
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  • Pidgeon GP, Tang K, Cai YL, Piasentin E, Honn KV
    "Overexpression of platelet-type 12-lipoxygenase promotes tumor cell survival by enhancing alpha(v)beta(3) and alpha(v)beta(5) integrin expression."
    Cancer Res 63: 4258-4267 (2003)
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  • Zhi H , Zhang J , Hu G , Lu J , Wang X , Zhou C , Wu M , Liu Z
    "The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma."
    Int J Cancer 106: 327-333 (2003)
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  • Pidgeon G.P., Kandouz M., Meram A., Honn K.V.
    "Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells."
    Cancer Res. 62: 2721-2727 (2002)
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  • Whitman S , Gezginci M , Timmermann BN , Holman TR
    "Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase."
    J Med Chem 45: 2659-2661 (2002)
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  • Winer I, Normolle DP, Shureiqi I, Sondak VK, Johnson T, Su L, Brenner DE
    "Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis."
    Melanoma Res 12: 429-434 (2002)
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  • Chen CJ , Huang HS , Chang WC
    "Inhibition of arachidonate metabolism in human epidermoid carcinoma a431 cells overexpressing phospholipid hydroperoxide glutathione peroxidase."
    J Biomed Sci 9: 453-459 (2002)
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  • Tong WG, Ding XZ, Adrian TE
    "The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells."
    Biochem Biophys Res Commun 296: 942-948 (2002)
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  • Chen BK, Tsai TY, Huang HS, Chen LC, Chang WC, Tsai SB, Chang WC
    "Functional Role of Extracellular Signal-Regulated Kinase Activation and c-Jun Induction in Phorbol Ester-Induced Promoter Activation of Human 12(S)-Lipoxygenase Gene."
    J Biomed Sci 9: 156-165 (2002)
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  • Shureiqi I., Lippman S.M.
    "Lipoxygenase Modulation to Reverse Carcinogenesis"
    Cancer Res. 61: 6307-6312 (2001)
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  • Schewe T., Sadik C., Klotz L.O., Yoshimoto T., Kuhn H., Sies H.
    "Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase."
    Biol. Chem. 382: 1687-1696 (2001)
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  • Limor R, Weisinger G, Gilad S, Knoll E, Sharon O, Jaffe A, Kohen F, Berger E, Lifschizt-Mercer B, Stern N
    "A novel form of platelet-type 12-lipoxygenase mRNA in human vascular smooth muscle cells."
    Hypertension 38: 864-871 (2001)
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  • Wong BC, Wang WP, Cho CH, Fan XM, Lin MC, Kung HF, Lam SK
    "12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells."
    Carcinogenesis 22: 1349-1354 (2001)
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  • Calzada C, Vericel E, Mitel B, Coulon L, Lagarde M
    "12(S)-Hydroperoxy-eicosatetraenoic acid increases arachidonic acid availability in collagen-primed platelets."
    J Lipid Res 42: 1467-1473 (2001)
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  • Liu C, Cheng R, Sun LQ, Tien P
    "Suppression of platelet-type 12-lipoxygenase activity in human erythroleukemia cells by an RNA-cleaving DNAzyme."
    Biochem Biophys Res Commun 284: 1077-1082 (2001)
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  • Sutherland M, Shankaranarayanan P, Schewe T, Nigam S
    "Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism."
    Biochem J 353: 91-100 (2001)
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  • Tornhamre S., Elmqvist A., Lindgren J.A.
    "15-Lipoxygenation of leukotriene A(4). Studies Of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation."
    Biochim. Biophys. Acta 1484: 298-306 (2000)
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  • Suzuki H, Ueda T, Juranek I, Yamamoto S, Katoh T, Node M, Suzuki T
    "Hinokitiol, a selective inhibitor of the platelet-type isozyme of arachidonate 12-lipoxygenase."
    Biochem Biophys Res Commun 275: 885-889 (2000)
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  • Chen CJ, Huang HS, Lin SB, Chang WC
    "Regulation of cyclooxygenase and 12-lipoxygenase catalysis by phospholipid hydroperoxide glutathione peroxidase in A431 cells."
    Prostaglandins Leukot Essent Fatty Acids 62: 261-268 (2000)
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  • Tim inverted question markar J, R inverted question markas inverted question marko E, D]ome B, Li L, Grignon D, Nie D, Honn KV, Hagmann W
    "Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential."
    Int J Cancer 87: 37-43 (2000)
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  • Liu C, Sun LQ, Tien P
    "Ribozyme-mediated suppression of platelet type 12 lipoxygenase in human erythroleukemia cells."
    Cancer Gene Ther 7: 671-675 (2000)
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  • Tang K , Finley RL Jr , Nie D , Honn KV
    "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening."
    Biochemistry 39: 3185-3191 (2000)
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  • Chen BK, Kung HC, Tsai TY, Chang WC
    "Essential role of mitogen-activated protein kinase pathway and c-Jun induction in epidermal growth factor-induced gene expression of human 12-lipoxygenase."
    Mol Pharmacol 57: 153-161 (2000)
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  • Conrad DJ, Lu M
    "Regulation of human 12/15-lipoxygenase by Stat6-dependent transcription."
    Am J Respir Cell Mol Biol 22: 226-234 (2000)
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  • Timar J , Raso E , Honn KV , Hagmann W
    "12-lipoxygenase expression in human melanoma cell lines."
    Adv Exp Med Biol 469: 617-622 (1999)
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  • Ozeki Y, Nagamura Y, Ito H, Unemi F, Kimura Y, Igawa T, Kambayashi J, Takahashi Y, Yoshimoto T
    "An anti-platelet agent, OPC-29030, inhibits translocation of 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid production in human platelets."
    Br J Pharmacol 128: 1699-1704 (1999)
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  • Shram SI, Lazurkina TYu, Myasoyedov NF, Varfolomeyev SD
    "Enzyme self-inactivation is a main limitation of the preparation of eicosanoids. Enzymatic synthesis of thromboxane and 12(S)-hydroxytetraenoic acid."
    Appl Biochem Biotechnol 82: 37-56 (1999)
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  • Nie D , Hillman GG , Geddes T , Tang K , Pierson C , Grignon DJ , Honn KV
    "Platelet-type 12-lipoxygenase regulates angiogenesis in human prostate carcinoma."
    Adv Exp Med Biol 469: 623-630 (1999)
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  • Huang HS, Chen CJ, Suzuki H, Yamamoto S, Chang WC
    "Inhibitory effect of phospholipid hydroperoxide glutathione peroxidase on the activity of lipoxygenases and cyclooxygenases."
    Prostaglandins Other Lipid Mediat 58: 65-75 (1999)
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  • Nigam S, Kumar GS, Sutherland M, Schewe T, Ikawa H, Yamasaki Y, Ueda N, Yamamoto S
    "Metabolic suppression of platelet-type 12-lipoxygenase in human uterine cervix with invasive carcinoma."
    Int J Cancer 82: 827-831 (1999)
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  • Dadaian M, Westlund P
    "Albumin modifies the metabolism of hydroxyeicosatetraenoic acids via 12-lipoxygenase in human platelets."
    J Lipid Res 40: 940-947 (1999)
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  • Dailey LA, Imming P
    "12-Lipoxygenase: classification, possible therapeutic benefits from inhibition, and inhibitors."
    Curr Med Chem 6: 389-398 (1999)
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  • Lagarde M , Calzada C , Zakaroff A , Meskini N , Prigent AF , Vericel E
    "Biological relevance of the 12-lipoxygenase pathway for platelet and lymphocyte functions."
    Adv Exp Med Biol 447: 87-93 (1999)
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  • You KM, Jong HG, Kim HP
    "Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants."
    Arch Pharm Res 22: 18-24 (1999)
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  • Croset M , Bordet JC , Lagarde M
    "Inhibition of prostaglandin H synthase and activation of 12-lipoxygenase by 8,11,14,17-eicosatetraenoic acid in human endothelial cells and platelets."
    Biochem Pharmacol 57: 631-638 (1999)
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  • Juranek I , Suzuki H , Yamamoto S
    "Affinities of various mammalian arachidonate lipoxygenases and cyclooxygenases for molecular oxygen as substrate."
    Biochim Biophys Acta 1436: 509-518 (1999)
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  • Nie D , Hillman GG , Geddes T , Tang K , Pierson C , Grignon DJ , Honn KV
    "Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth."
    Cancer Res 58: 4047-4051 (1998)
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  • Edgemond WS, Hillard CJ, Falck JR, Kearn CS, Campbell WB
    "Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivation."
    Mol Pharmacol 54: 180-188 (1998)
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  • Setty BN, Chen D, O'Neal P, Littrell JB, Grossman MH, Stuart MJ
    "Eicosanoids in sickle cell disease: potential relevance of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid to the pathophysiology of vaso-occlusion."
    J Lab Clin Med 131: 344-353 (1998)
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  • Tohjima T, Honda N, Mochizuki K, Kinoshita J, Watanabe K, Arisaka T, Kawamori R, Nakamura M, Kurahashi Y, Yoshimoto T, Yamamoto S
    "Decreased activity of arachidonate 12-lipoxygenase in platelets of Japanese patients with non-insulin-dependent diabetes mellitus."
    Metabolism 47: 257-263 (1998)
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  • Liaw YW , Liu YW , Chen BK , Chang WC
    "Induction of 12-lipoxygenase expression by phorbol 12-myristate 13-acetate in human epidermoid carcinoma A431 cells."
    Biochim Biophys Acta 1389: 23-33 (1998)
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  • Connolly JM, Rose DP
    "Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice."
    Cancer Lett 132: 107-112 (1998)
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  • Herbertsson H, Kuhme T, Evertsson U, Wigren J, Hammarstrom S
    "Identification of subunits of the 650 kDa 12(S)-HETE binding complex in carcinoma cells."
    J Lipid Res 39: 237-244 (1998)
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  • Liagre B, Vergne P, Rigaud M, Beneytout JL
    "Expression of arachidonate platelet-type 12-lipoxygenase in human rheumatoid arthritis type B synoviocytes."
    FEBS Lett 414: 159-164 (1997)
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  • Tomo K, Takayama H, Okuma M
    "Age-related changes of platelet arachidonic acid metabolism in normal subjects."
    Int J Hematol 66: 249-251 (1997)
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  • Nakamura M, Yamamoto S, Ishimura K
    "Subcellular localization of arachidonate 12-lipoxygenase and morphological effect of its overexpression on murine keratinocytes."
    Cell Tissue Res 288: 327-334 (1997)
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  • Tomo K, Takayama H, Kaneko Y, Fujita J, Nakamura M, Ueda N, Yamamoto S, Okuma M
    "Qualitative platelet 12-lipoxygenase abnormality in a patient with essential thrombocythemia."
    Thromb Haemost 77: 294-297 (1997)
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  • Reynaud D, Pace-Asciak CR
    "12-HETE and 12-HPETE potently stimulate intracellular release of calcium in intact human neutrophils."
    Prostaglandins Leukot Essent Fatty Acids 56: 9-12 (1997)
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  • Liu YW, Arakawa T, Yamamoto S, Chang WC
    "Transcriptional activation of human 12-lipoxygenase gene promoter is mediated through Sp1 consensus sites in A431 cells."
    Biochem J 324: 133-140 (1997)
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  • Chen CJ, Huang HS, Lee YT, Yang CY, Chang WC
    "Characterization and purification of a lipoxygenase inhibitor in human epidermoid carcinoma A431 cells."
    Biochem J 327: 193-198 (1997)
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  • Hagmann W
    "Lipoxygenase in Human Tumor Cells."
    Pathol Oncol Res 3: 83-88 (1997)
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  • Chen BK, Liu YW, Yamamoto S, Chang WC
    "Overexpression of Ha-ras enhances the transcription of human arachidonate 12-lipoxygenase promoter in A431 cells."
    Biochim Biophys Acta 1344: 270-277 (1997)
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  • Li Y, Maher P, Schubert D
    "A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion."
    Neuron 19: 453-463 (1997)
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  • Liu YW, Chen BK, Chen CJ, Arakawa T, Yoshimoto T, Yamamoto S, Chang WC
    "Epidermal growth factor enhances transcription of human arachidonate 12-lipoxygenase in A431 cells."
    Biochim Biophys Acta 1344: 38-46 (1997)
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  • Timar J, Raso E, Fazakas ZS, Silletti S, Raz A, Honn KV
    "Multiple use of a signal transduction pathway in tumor cell invasion."
    Anticancer Res 16: 3299-3306 (1996)
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  • Hagmann W, Gao X, Timar J, Chen YQ, Strohmaier AR, Fahrenkopf C, Kagawa D, Lee M, Zacharek A, Honn KV
    "12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization."
    Exp Cell Res 228: 197-205 (1996)
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  • Kaminski WE, Jendraschak E, Baumann K, Kiefl R, Fischer S, Marcus AJ, Broekman MJ, von Schacky C
    "Human mononuclear cells express 12-LX: coordinated mRNA regulation with 5-LX and FLAP genes."
    Blood 87: 331-340 (1996)
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  • Liu XH, Connolly JM, Rose DP
    "The 12-lipoxygenase gene-transfected MCF-7 human breast cancer cell line exhibits estrogen-independent, but estrogen and omega-6 fatty acid-stimulated proliferation in vitro, and enhanced growth in athymic nude mice."
    Cancer Lett 109: 223-230 (1996)
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  • Ueda N, Yamamoto K., Yamamoto S., Tokunaga T., Shirakawa E., Shinkai H., Ogawa M., Sato T., Kudo I., Inoue K., et al.
    "Lipoxygenase-catalyzed oxygenation of arachidonylethanolamide, a cannabinoid receptor agonist."
    Biochim. Biophys. Acta 1254: 127-134 (1995)
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  • Arakawa T, Nakamura M, Yoshimoto T, Yamamoto S
    "The transcriptional regulation of human arachidonate 12-lipoxygenase gene by NF kappa B/Rel."
    FEBS Lett 363: 105-110 (1995)
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  • Kim JA, Gu JL, Natarajan R, Berliner JA, Nadler JL
    "A leukocyte type of 12-lipoxygenase is expressed in human vascular and mononuclear cells. Evidence for upregulation by angiotensin II."
    Arterioscler Thromb Vasc Biol 15: 942-948 (1995)
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  • Chen YQ, Duniec ZM, Liu B, Hagmann W, Gao X, Shimoji K, Marnett LJ, Johnson CR, Honn KV
    "Endogenous 12(S)-HETE production by tumor cells and its role in metastasis."
    Cancer Res 54: 1574-1579 (1994)
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  • Honn KV, Timar J, Rozhin J, Bazaz R, Sameni M, Ziegler G, Sloane BF
    "A lipoxygenase metabolite, 12-(S)-HETE, stimulates protein kinase C-mediated release of cathepsin B from malignant cells."
    Exp Cell Res 214: 120-130 (1994)
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  • Hussain H, Shornick LP, Shannon VR, Wilson JD, Funk CD, Pentland AP, Holtzman MJ
    "Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis."
    Am J Physiol 266: C243-53 (1994)
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  • Liu YW, Asaoka Y, Suzuki H, Yoshimoto T, Yamamoto S, Chang WC
    "Induction of 12-lipoxygenase expression by epidermal growth factor is mediated by protein kinase C in A431 cells."
    J Pharmacol Exp Ther 271: 567-573 (1994)
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  • Nakatsuka M, Osawa Y
    "Selective inhibition of the 12-lipoxygenase pathway of arachidonic acid metabolism by L-arginine or sodium nitroprusside in intact human platelets."
    Biochem Biophys Res Commun 200: 1630-1634 (1994)
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  • Bell RL, Brooks DW, Young PR, Lanni C, Stewart AO, Bouska J, Malo PE, Carter GW
    "A-78773: a selective, potent 5-lipoxygenase inhibitor."
    J Lipid Mediat 6: 259-264 (1993)
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  • Romano M, Chen XS, Takahashi Y, Yamamoto S, Funk CD, Serhan CN
    "Lipoxin synthase activity of human platelet 12-lipoxygenase."
    Biochem J 296: 127-133 (1993)
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  • Arenberger P, Kemeny L, Ruzicka T
    "Characterization of high-affinity 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) binding sites on normal human keratinocytes."
    Epithelial Cell Biol 2: 1-6 (1993)
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  • Chang WC, Liu YW, Ning CC, Suzuki H, Yoshimoto T, Yamamoto S
    "Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells."
    J Biol Chem 268: 18734-18739 (1993)
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  • Chen XS, Brash AR, Funk CD
    "Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system."
    Eur J Biochem 214: 845-852 (1993)
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  • Chen XS, Funk CD
    "Structure-function properties of human platelet 12-lipoxygenase: chimeric enzyme and in vitro mutagenesis studies."
    FASEB J 7: 694-701 (1993)
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  • Matsuda S, Murakami J, Yamamoto Y, Konishi Y, Yokoyama C, Yoshimoto T, Yamamoto S, Mimura Y, Okuma M
    "Decreased messenger RNA of arachidonate 12-lipoxygenase in platelets of patients with myeloproliferative disorders."
    Biochim Biophys Acta 1180: 243-249 (1993)
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  • Shannon VR, Stenson WF, Holtzman MJ
    "Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease."
    Am J Physiol 264: G104-11 (1993)
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  • Takahashi Y , Reddy GR , Ueda N , Yamamoto S , Arase S
    "Arachidonate 12-lipoxygenase of platelet-type in human epidermal cells."
    J Biol Chem 268: 16443-16448 (1993)
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  • Funk C.D., Funk L.B., Fitzgerald G.A., Samuelsson B.
    "Characterization of human 12-lipoxygenase genes."
    Proc. Natl. Acad. Sci. U.S.A. 89: 3962-3966 (1992)
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  • Yoshimoto T, Arakawa T, Hada T, Yamamoto S, Takahashi E
    "Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene."
    J Biol Chem 267: 24805-24809 (1992)
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  • Ruzicka T
    "The role of the epidermal 12-hydroxyeicosatetraenoic acid receptor in the skin."
    Eicosanoids 5: S63-5 (1992)
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  • Funk CD, FitzGerald GA
    "Eicosanoid forming enzyme mRNA in human tissues. Analysis by quantitative polymerase chain reaction."
    J Biol Chem 266: 12508-12513 (1991)
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  • Funk C.D., Furci L., Fitzgerald G.A.
    "Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase."
    Proc. Natl. Acad. Sci. U.S.A. 87: 5638-5642 (1990)
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  • Izumi T., Hoshiko S., Radmark O., Samuelsson B.
    "Cloning of the cDNA for human 12-lipoxygenase."
    Proc. Natl. Acad. Sci. U.S.A. 87: 7477-7481 (1990)
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  • Yoshimoto T, Yamamoto Y, Arakawa T, Suzuki H, Yamamoto S, Yokoyama C, Tanabe T, Toh H
    "Molecular cloning and expression of human arachidonate 12-lipoxygenase."
    Biochem Biophys Res Commun 172: 1230-1235 (1990)
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