Deutsches Krebsforschungszentrum 
German Cancer Resarch CenterLOX-DB - LipOXygenases DataBase
Lipoxygenases...
What are Lipoxygenases?
Lipoxygenases and
cancer research
Database...
Search
Display all entries
Alignments
Sequence Comparison
Blast Search
Search Literature
Search Literature (adv.)
Misc...
Image Gallery
Links
Forum
Contact
Guestbook
Home

LOX-DB - Literature related to h-15-lox


Found 68 entries:

  • Cichewicz RH , Kenyon VA , Whitman S , Morales NM , Arguello JF , Holman TR , Crews P
    "Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors."
    J Am Chem Soc 126: 14910-14920 (2004)
    more...

  • Chaitidis P , Kreutzer FJ , Gerth C , Janata P , Kuhn H
    "Impact of intravenous oxygen therapy on the expression of reticulocyte-type 15-lipoxygenase in human volunteers."
    Prostaglandins Leukot Essent Fatty Acids 71: 271-276 (2004)
    more...

  • Ivanov I, Romanov S, Ozdoba C, Holzhutter HG, Myagkova G, Kuhn H
    "Enantioselective substrate specificity of 15-lipoxygenase 1."
    Biochemistry 43: 15720-15728 (2004)
    more...

  • Hsi LC, Xi X, Lotan R, Shureiqi I, Lippman SM
    "The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells."
    Cancer Res 64: 8778-81 (2004)
    more...

  • Segraves EN , Holman TR
    "Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase."
    Biochemistry 42: 5236-5243 (2003)
    more...

  • Jiang WG, Douglas-Jones A, Mansel RE
    "Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer."
    Prostaglandins Leukot Essent Fatty Acids 69: 275-281 (2003)
    more...

  • Shureiqi I., Jiang W., Fischer S.M., Xu X., Chen D., Lee J.J., Lotan R., Lippman S.M.
    "GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells."
    Cancer Res. 62: 1178-1183 (2002)
    more...

  • Kozak K.R., Gupta R.A., Moody J.S., Ji C., Boeglin W.E., DuBois R.N., Brash A.R., Marnett L.J.
    "15-lipoxygenase metabolism of 2-arachidonylglycerol: Generation of a PPARalpha agonist."
    J. Biol. Chem. 277: 23278-23286 (2002)
    more...

  • Whitman S , Gezginci M , Timmermann BN , Holman TR
    "Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase."
    J Med Chem 45: 2659-2661 (2002)
    more...

  • Schewe T
    "15-lipoxygenase-1: a prooxidant enzyme."
    Biol Chem 383: 365-374 (2002)
    more...

  • Yang XY, Wang LH, Mihalic K, Xiao W, Chen T, Li P, Wahl LM, Farrar WL
    "Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor gamma activated by macrophage-derived 12/15-lipoxygenase ligands."
    J Biol Chem 277: 3973-3978 (2002)
    more...

  • Shureiqi I., Lippman S.M.
    "Lipoxygenase Modulation to Reverse Carcinogenesis"
    Cancer Res. 61: 6307-6312 (2001)
    more...

  • Kelavkar U.P., Nixon J.B., Cohen C., Dillehay D., Eling T.E., Badr K.F.
    "Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis."
    Carcinogenesis 22: 1765-1773 (2001)
    more...

  • Heydeck D, Upston JM, Viita H, Yla-Herttuala S, Stocker R
    "Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions."
    J Lipid Res 42: 1082-1088 (2001)
    more...

  • Tornhamre S., Elmqvist A., Lindgren J.A.
    "15-Lipoxygenation of leukotriene A(4). Studies Of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation."
    Biochim. Biophys. Acta 1484: 298-306 (2000)
    more...

  • Cathcart MK, Folcik VA
    "Lipoxygenases and atherosclerosis: protection versus pathogenesis."
    Free Radic Biol Med 28: 1726-1734 (2000)
    more...

  • Harats D, Shaish A, George J, Mulkins M, Kurihara H, Levkovitz H, Sigal E
    "Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice."
    Arterioscler Thromb Vasc Biol 20: 2100-2105 (2000)
    more...

  • Kamitani H, Kameda H, Kelavkar UP, Eling TE
    "A GATA binding site is involved in the regulation of 15-lipoxygenase-1 expression in human colorectal carcinoma cell line, caco-2."
    FEBS Lett 467: 341-347 (2000)
    more...

  • Montero A, Badr KF
    "15-Lipoxygenase in glomerular inflammation."
    Exp Nephrol 8: 14-19 (2000)
    more...

  • Profita M, Sala A, Riccobono L, Pace E, Paterno A, Zarini S, Siena L, Mirabella A, Bonsignore G, Vignola AM
    "15(S)-HETE modulates LTB(4) production and neutrophil chemotaxis in chronic bronchitis."
    Am J Physiol Cell Physiol 279: C1249-58 (2000)
    more...

  • Kelavkar U.P., Badr K.F.
    "Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene."
    Proc. Natl. Acad. Sci. U.S.A. 96: 4378-4383 (1999)
    more...

  • Hong SH, Avis I, Vos MD, Martinez A, Treston AM, Mulshine JL
    "Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors."
    Cancer Res 59: 2223-2228 (1999)
    more...

  • Viita H, Sen CK, Roy S, Siljamaki T, Nikkari T, Yla-Herttuala S
    "High expression of human 15-lipoxygenase induces NF-kappaB-mediated expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and T-cell adhesion on human endothelial cells."
    Antioxid Redox Signal 1: 83-96 (1999)
    more...

  • Yamashita H, Nakamura A, Noguchi N, Niki E, Kuhn H
    "Oxidation of low density lipoprotein and plasma by 15-lipoxygenase and free radicals."
    FEBS Lett 445: 287-290 (1999)
    more...

  • Huang JT, Welch JS, Ricote M, Binder CJ, Willson TM, Kelly C, Witztum JL, Funk CD, Conrad D, Glass CK
    "Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase."
    Nature 400: 378-382 (1999)
    more...

  • Heydeck D, Thomas L, Schnurr K, Trebus F, Thierfelder WE, Ihle JN, Kuhn H
    "Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6."
    Blood 92: 2503-2510 (1998)
    more...

  • Sendobry SM, Cornicelli JA, Welch K, Grusby MJ, Daugherty A
    "Absence of T lymphocyte-derived cytokines fails to diminish macrophage 12/15-lipoxygenase expression in vivo."
    J Immunol 161: 1477-1482 (1998)
    more...

  • Ivanov I, Schwarz K, Holzhutter HG, Myagkova G, Kuhn H
    "Omega-oxidation impairs oxidizability of polyenoic fatty acids by 15-lipoxygenases: consequences for substrate orientation at the active site."
    Biochem J 336: 345-352 (1998)
    more...

  • Hill EM, Eling T, Nettesheim P
    "Differentiation dependency of eicosanoid enzyme expression in human tracheobronchial cells."
    Toxicol Lett 96: 239-244 (1998)
    more...

  • Kelavkar U , Wang S , Montero A , Murtagh J , Shah K , Badr K
    "Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes."
    Mol Biol Rep 25: 173-182 (1998)
    more...

  • Kritzik MR, Ziober AF, Dicharry S, Conrad DJ, Sigal E
    "Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene."
    Biochim Biophys Acta 1352: 267-281 (1997)
    more...

  • Feinmark SJ, Cornicelli JA
    "Is there a role for 15-lipoxygenase in atherogenesis?"
    Biochem Pharmacol 54: 953-959 (1997)
    more...

  • Upston JM, Neuzil J, Witting PK, Alleva R, Stocker R
    "Oxidation of free fatty acids in low density lipoprotein by 15-lipoxygenase stimulates nonenzymic, alpha-tocopherol-mediated peroxidation of cholesteryl esters."
    J Biol Chem 272: 30067-30074 (1997)
    more...

  • Gan Q.F., Browner M.F., Sloane D.L., Sigal E.
    "Defining the arachidonic acid binding site of human 15-lipoxygenase. Molecular modeling and mutagenesis."
    J. Biol. Chem. 271: 25412-25418 (1996)
    more...

  • Borngraber S., Kuban R.J., Anton M., Kuhn H.
    "Phenylalanine 353 is a primary determinant for the positional specificity of mammalian 15-lipoxygenases."
    J. Mol. Biol. 264: 1145-1153 (1996)
    more...

  • Kaminski WE, Jendraschak E, Baumann K, Kiefl R, Fischer S, Marcus AJ, Broekman MJ, von Schacky C
    "Human mononuclear cells express 12-LX: coordinated mRNA regulation with 5-LX and FLAP genes."
    Blood 87: 331-340 (1996)
    more...

  • Bailey JM, Lee R, Simon T
    "Activation of 12- and 15-lipoxygenase in the cardiopulmonary system by hemorrhagic events."
    Biochem Soc Trans 24: 435S (1996)
    more...

  • Brinckmann R, Topp MS, Zalan I, Heydeck D, Ludwig P, Kuhn H, Berdel WE, Habenicht JR
    "Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4."
    Biochem J 318: 305-312 (1996)
    more...

  • Upston JM, Neuzil J, Stocker R
    "Oxidation of LDL by recombinant human 15-lipoxygenase: evidence for alpha-tocopherol-dependent oxidation of esterified core and surface lipids."
    J Lipid Res 37: 2650-2661 (1996)
    more...

  • Shen J, Kuhn H, Petho-Schramm A, Chan L
    "Transgenic rabbits with the integrated human 15-lipoxygenase gene driven by a lysozyme promoter: macrophage-specific expression and variable positional specificity of the transgenic enzyme."
    FASEB J 9: 1623-1631 (1995)
    more...

  • Benz DJ, Mol M, Ezaki M, Mori-Ito N, Zelan I, Miyanohara A, Friedmann T, Parthasarathy S, Steinberg D, Witztum JL
    "Enhanced levels of lipoperoxides in low density lipoprotein incubated with murine fibroblast expressing high levels of human 15-lipoxygenase."
    J Biol Chem 270: 5191-5197 (1995)
    more...

  • Bradding P , Redington AE , Djukanovic R , Conrad DJ , Holgate ST
    "15-lipoxygenase immunoreactivity in normal and in asthmatic airways."
    Am J Respir Crit Care Med 151: 1201-1204 (1995)
    more...

  • Folcik VA , Nivar-Aristy RA , Krajewski LP , Cathcart MK
    "Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques."
    J Clin Invest 96: 504-510 (1995)
    more...

  • Gan QF, Witkop GL, Sloane DL, Straub KM, Sigal E
    "Identification of a specific methionine in mammalian 15-lipoxygenase which is oxygenated by the enzyme product 13-HPODE: dissociation of sulfoxide formation from self-inactivation."
    Biochemistry 34: 7069-7079 (1995)
    more...

  • Sloane DL, Leung R, Barnett J, Craik CS, Sigal E
    "Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity."
    Protein Eng 8: 275-282 (1995)
    more...

  • Zhao H, Richards-Smith B, Baer AN, Green FA
    "Lipoxygenase mRNA in cultured human epidermal and oral keratinocytes."
    J Lipid Res 36: 2444-2449 (1995)
    more...

  • Kuhn H., Belkner J., Suzuki H., Yamamoto S.
    "Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities."
    J. Lipid Res. 35: 1749-1759 (1994)
    more...

  • Liminga M, Hornsten L, Sprecher HW, Oliw EH
    "Arachidonate 15-lipoxygenase in human corneal epithelium and 12- and 15-lipoxygenases in bovine corneal epithelium: comparison with other bovine 12-lipoxygenases."
    Biochim Biophys Acta 1210: 288-296 (1994)
    more...

  • Sigal E, Conrad DJ
    "Human 15-lipoxygenase: a potential effector molecule for interleukin-4."
    Adv Prostaglandin Thromboxane Leukot Res 22: 309-316 (1994)
    more...

  • Sigal E , Sloane DL , Conrad DJ
    "Human 15-lipoxygenase: induction by interleukin-4 and insights into positional specificity."
    J Lipid Mediat 6: 75-88 (1993)
    more...

  • Baer AN, Green FA
    "Fatty acid oxygenase activity of human hair roots."
    J Lipid Res 34: 1505-1514 (1993)
    more...

  • Kuhn H, Barnett J, Grunberger D, Baecker P, Chow J, Nguyen B, Bursztyn-Pettegrew H, Chan H, Sigal E
    "Overexpression, purification and characterization of human recombinant 15-lipoxygenase."
    Biochim Biophys Acta 1169: 80-89 (1993)
    more...

  • O'Leary VJ, Darley-Usmar VM, Russell LJ, Stone D
    "Pro-oxidant effects of lipoxygenase-derived peroxides on the copper-initiated oxidation of low-density lipoprotein."
    Biochem J 282: 631-634 (1992)
    more...

  • Conrad DJ, Kuhn H, Mulkins M, Highland E, Sigal E
    "Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase."
    Proc Natl Acad Sci U S A 89: 217-221 (1992)
    more...

  • Sigal E, Dicharry S, Highland E, Finkbeiner WE
    "Cloning of human airway 15-lipoxygenase: identity to the reticulocyte enzyme and expression in epithelium."
    Am J Physiol 262: L392-8 (1992)
    more...

  • Izumi T., Raadmark O., Joernvall H., Samuelsson B.
    "Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes."
    Eur. J. Biochem. 202: 1231-1238 (1991)
    more...

  • Sloane D.L., Leung R., Craik C.S., Sigal E.
    "A primary determinant for lipoxygenase positional specificity."
    Nature 354: 149-152 (1991)
    more...

  • Ford-Hutchinson AW
    "Arachidonate 15-lipoxygenase; characteristics and potential biological significance."
    Eicosanoids 4: 65-74 (1991)
    more...

  • Funk CD, FitzGerald GA
    "Eicosanoid forming enzyme mRNA in human tissues. Analysis by quantitative polymerase chain reaction."
    J Biol Chem 266: 12508-12513 (1991)
    more...

  • Yla-Herttuala S , Rosenfeld ME , Parthasarathy S , Sigal E , Sarkioja T , Witztum JL , Steinberg D
    "Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts."
    J Clin Invest 87: 1146-1152 (1991)
    more...

  • Green FA
    "Transformations of 5-HETE by activated keratinocyte 15-lipoxygenase and the activation mechanism."
    Lipids 25: 618-623 (1990)
    more...

  • Sloane DL, Craik CS, Sigal E
    "The expression of active human reticulocyte 15-lipoxygenase in bacteria."
    Biomed Biochim Acta 49: S11-6 (1990)
    more...

  • Yla-Herttuala S, Rosenfeld ME, Parthasarathy S, Glass CK, Sigal E, Witztum JL, Steinberg D
    "Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions."
    Proc Natl Acad Sci U S A 87: 6959-6963 (1990)
    more...

  • Sigal E., Craik C.S., Highland E., Grunberger D., Costello L.L., Dixon R.A.F., Nadel J.A.
    "Molecular cloning and primary structure of human 15-lipoxygenase."
    Biochem. Biophys. Res. Commun. 157: 457-464 (1988)
    more...

  • Sigal E., Grunberger D., Craik C.S., Caughey G.H., Nadel J.A.
    "Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases."
    J. Biol. Chem. 263: 5328-5332 (1988)
    more...

  • Burrall BA, Cheung M, Chiu A, Goetzl EJ
    "Enzymatic properties of the 15-lipoxygenase of human cultured keratinocytes."
    J Invest Dermatol 91: 294-297 (1988)
    more...

  • Kragballe K, Voorhees JJ
    "Eicosanoids in psoriasis--15-HETE on the stage."
    Dermatologica 174: 209-213 (1987)
    more...

  • Jung G, Yang DC, Nakao A
    "Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenase."
    Biochem Biophys Res Commun 130: 559-566 (1985)
    more...