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Glycosciences.DB structure entry #673: 3'-Sialyllactosamin

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Format: CarbBank LINUCS GlycoCT_condensed GlycoCT_xml


 a-D-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc


RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
5s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(4+1)3d
3:3o(3+2)4d
4:4d(5+1)5n


<?xml version="1.0" encoding="UTF-8"?>
 <sugar version="1.0">
 <residues>
 <basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dglc-HEX-1:5">
 <stemtype id="1" type="dglc" />
 </basetype>
 <substituent id="2" name="n-acetyl" />
 <basetype id="3" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
 <stemtype id="1" type="dgal" />
 </basetype>
 <basetype id="4" anomer="a" superclass="non" ringStart="2" ringEnd="6" name="a-dgro-dgal-NON-2:6|1:a|2:keto|3:d">
 <stemtype id="1" type="dgro" />
 <stemtype id="2" type="dgal" />
 <modification type="a" pos_one="1" />
 <modification type="keto" pos_one="2" />
 <modification type="d" pos_one="3" />
 </basetype>
 <substituent id="5" name="n-acetyl" />
 </residues>
 <linkages>
 <connection id="1" parent="1" child="2">
 <linkage id="1" parentType="d" childType="n">
 <parent pos="2" />
 <child pos="1" />
 </linkage>
 </connection>
 <connection id="2" parent="1" child="3">
 <linkage id="2" parentType="o" childType="d">
 <parent pos="4" />
 <child pos="1" />
 </linkage>
 </connection>
 <connection id="3" parent="3" child="4">
 <linkage id="3" parentType="o" childType="d">
 <parent pos="3" />
 <child pos="2" />
 </linkage>
 </connection>
 <connection id="4" parent="4" child="5">
 <linkage id="4" parentType="d" childType="n">
 <parent pos="5" />
 <child pos="1" />
 </linkage>
 </connection>
 </linkages>
 </sugar>

SNFG-style Graphics

3D Structure Model

download coordinates

Corresponding entries: 13

1 - 5 of 13 entries with matching glycan part

Structure entry #285:

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-4)-Asn

NMR spectra

literature references

no GlycoMaps

Structure entry #523:

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-Methyl

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #2281:

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-allyl

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #3243:

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-2-propenamide

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #4516:

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-ethanolamine

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Lactosamine (Show) (Search Database)

3'-Sialyllactosamin
3'-SLN
3'SLN
3SLN
3'Sia-LacNAc

General Structure Data

Chemical Formula:	C₂₅H₄₂N₂O₁₉		#C	#H	#O	#N
Molec. Weight:	674		25	42	19	2
# Atoms:	88
# Residues:	3
# Heavy Atoms:	46

Superclasses:

Neu		Hex
NeuAc	1	Hex	1
		HexNAc	1

Residues:

Residue	Count
A-D-NEUP5AC	1
B-D-GALP	1
B-D-GLCPNAC	1

PDB references: 49

1 - 5 of 49 PDB entries

PDB ID 7kmj: Hsa Siglec and Unique domains in complex with Sialyl Lewis C

Description:

Source: Streptococcus gordonii str. Challis

Experimental method: X-RAY DIFFRACTION

Resolution: 1.33Å

Release date: 2022-05-25

Entry features 1 distinct glycan structures [1 instances].

PDB ID 6p4m: Salmonella typhi PltB Homopentamer with Neu5Ac-alpha-2-3-Gal-beta-1-4-GlcNAc Glycans

Description: Putative pertussis-like toxin subunit

Source: Salmonella enterica subsp. enterica serovar Typhi str. CT18

Experimental method: X-RAY DIFFRACTION

Resolution: 1.802Å

Release date: 2020-03-25

Entry features 1 distinct glycan structures [9 instances].

PDB ID 6p4q: Salmonella typhi PltB Homopentamer N29K Mutant with Neu5Ac-alpha-2-3-Gal-beta-1-4-GlcNAc Glycans

Description: Putative pertussis-like toxin subunit

Source: Salmonella enterica subsp. enterica serovar Typhi str. CT18

Experimental method: X-RAY DIFFRACTION

Resolution: 1.77Å

Release date: 2020-03-25

Entry features 1 distinct glycan structures [6 instances].

PDB ID 6p4t: Salmonella typhi PltB Homopentamer T65I Mutant with Neu5Ac-alpha-2-3-Gal-beta-1-4-GlcNAc Glycans

Description: Putative pertussis-like toxin subunit

Source: Salmonella enterica subsp. enterica serovar Typhi str. CT18

Experimental method: X-RAY DIFFRACTION

Resolution: 2.17Å

Release date: 2020-03-25

Entry features 1 distinct glycan structures [3 instances].

PDB ID 6idz: Crystal structure of H7 hemagglutinin mutant H7-SVTQ ( A138S, P221T, L226Q) with 3'SLN

Description: Hemagglutinin

Source: Influenza A virus

Experimental method: X-RAY DIFFRACTION

Resolution: 2.707Å

Release date: 2019-11-27

Entry features 2 distinct glycan structures [3 instances].

Literature references: 19

1 - 5 of 19 literature references

Reference #21602

Hyun JY; Kim S; Lee CH; Lee HS; Shin I

Efficient Preparation and Bioactivity Evaluation of Glycan-Defined Glycoproteins.

Published 2021 in ACS Chem Biol, 16: 1930-1940

Reference contains 9 structures

Reference #21727

Saha S; Coady A; Sasmal A; Kawanishi K; Choudhury B; Yu H; Sorensen RU; Inostroza J; Schoenhofen IC; Chen X; Münster-Kühnel A; Sato C; Kitajima K; Ram S; Nizet V; Varki A

Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae.

Published 2021 in mBio, 12:

Reference contains 10 structures

Reference #22000

Sojitra M; Sarkar S; Maghera J; Rodrigues E; Carpenter EJ; Seth S; Ferrer Vinals D; Bennett NJ; Reddy R; Khalil A; Xue X; Bell MR; Zheng RB; Zhang P; Nycholat C; Bailey JJ; Ling CC; Lowary TL; Paulson JC; Macauley MS; Derda R

Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage.

Published 2021 in Nat Chem Biol, 17: 806-816

Reference contains 65 structures

Reference #21674

Pongracz T; Verhoeven A; Wuhrer M; de Haan N

The structure and role of lactone intermediates in linkage-specific sialic acid derivatization reactions.

Published 2021 in Glycoconj J, 38: 157-166

Reference contains 2 structures

Reference #21703

Ezeabikwa B; Mondal N; Antonopoulos A; Haslam SM; Matsumoto Y; Martin-Caraballo M; Lehoux S; Mandalasi M; Ishaque A; Heimburg-Molinaro J; Cummings RD; Nyame AK

Major differences in glycosylation and fucosyltransferase expression in low-grade versus high-grade bladder cancer cell lines.

Published 2021 in Glycobiology, 31: 1444-1463

Reference contains 15 structures

Further literature references from PDB entries: 23

1 - 5 of 23 literature references from PDB entries

Reference #22163

Lee S; Yang YA; Milano SK; Nguyen T; Ahn C; Sim JH; Thompson AJ; Hillpot EC; Yoo G; Paulson JC; Song J

Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence.

Published 2020 in Cell Host Microbe, 27: 937-949.e6

Reference #20271

Wu NC; Xie J; Zheng T; Nycholat CM; Grande G; Paulson JC; Lerner RA; Wilson IA

Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.

Published 2017 in Cell Host Microbe, 21: 742-753.e8

Reference #20218

Tzarum N; de Vries RP; Peng W; Thompson AJ; Bouwman KM; McBride R; Yu W; Zhu X; Verheije MH; Paulson JC; Wilson IA

The 150-Loop Restricts the Host Specificity of Human H10N8 Influenza Virus.

Published 2017 in Cell Rep, 19: 235-245

Reference #20156

Loukachevitch LV; Bensing BA; Yu H; Zeng J; Chen X; Sullam PM; Iverson TM

Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand.

Published 2016 in Biochemistry, :

Reference #19385

Liu Y; Sheng J; Baggen J; Meng G; Xiao C; Thibaut HJ; van Kuppeveld FJ; Rossmann MG

Sialic acid-dependent cell entry of human enterovirus D68.

Published 2015 in Nat Commun, 6: 8865

NCBI Taxonomy ID	Scientific Name
9606	Homo sapiens

Consortium for Functional Glycomics (CFG):

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