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Glycosciences.DB structure entry #6656: 6'-Sialyllactosamin

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Format: CarbBank LINUCS GlycoCT_condensed GlycoCT_xml


 a-D-Neup5Ac-(2-6)-b-D-Galp-(1-4)-b-D-GlcpNAc


RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
5s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(4+1)3d
3:3o(6+2)4d
4:4d(5+1)5n


<?xml version="1.0" encoding="UTF-8"?>
 <sugar version="1.0">
 <residues>
 <basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dglc-HEX-1:5">
 <stemtype id="1" type="dglc" />
 </basetype>
 <substituent id="2" name="n-acetyl" />
 <basetype id="3" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
 <stemtype id="1" type="dgal" />
 </basetype>
 <basetype id="4" anomer="a" superclass="non" ringStart="2" ringEnd="6" name="a-dgro-dgal-NON-2:6|1:a|2:keto|3:d">
 <stemtype id="1" type="dgro" />
 <stemtype id="2" type="dgal" />
 <modification type="a" pos_one="1" />
 <modification type="keto" pos_one="2" />
 <modification type="d" pos_one="3" />
 </basetype>
 <substituent id="5" name="n-acetyl" />
 </residues>
 <linkages>
 <connection id="1" parent="1" child="2">
 <linkage id="1" parentType="d" childType="n">
 <parent pos="2" />
 <child pos="1" />
 </linkage>
 </connection>
 <connection id="2" parent="1" child="3">
 <linkage id="2" parentType="o" childType="d">
 <parent pos="4" />
 <child pos="1" />
 </linkage>
 </connection>
 <connection id="3" parent="3" child="4">
 <linkage id="3" parentType="o" childType="d">
 <parent pos="6" />
 <child pos="2" />
 </linkage>
 </connection>
 <connection id="4" parent="4" child="5">
 <linkage id="4" parentType="d" childType="n">
 <parent pos="5" />
 <child pos="1" />
 </linkage>
 </connection>
 </linkages>
 </sugar>

SNFG-style Graphics

3D Structure Model

download coordinates

Corresponding entries: 9

1 - 5 of 9 entries with matching glycan part

Structure entry #284:

a-D-Neup5Ac-(2-6)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-4)-Asn

NMR spectra

literature references

no GlycoMaps

Structure entry #524:

a-D-Neup5Ac-(2-6)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-Methyl

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #598:

a-D-Neup5Ac-(2-6)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-4)+ | Asn-(1-2)-Ser-(1-2)-Thr-(1-2)-Ile | <(allyloxy)carbonyl>-(1-2)-Phe-(1-2)+

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #599:

a-D-Neup5Ac-(2-6)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-4)+ | Asn-(1-2)-Gly-(1-2)-Gly | Gly-(1-2)-Gly-(1-2)+

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #14349:

a-D-Neup5Ac-(2-6)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-Pent-4-en-1-ol

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Lactosamine (Show) (Search Database)

6'-Sialyllactosamin
6SLN
6'-SLN
6'SLN

General Structure Data

Chemical Formula:	C₂₅H₄₂N₂O₁₉		#C	#H	#O	#N
Molec. Weight:	674		25	42	19	2
# Atoms:	88
# Residues:	3
# Heavy Atoms:	46

Superclasses:

Neu		Hex
NeuAc	1	Hex	1
		HexNAc	1

Residues:

Residue	Count
A-D-NEUP5AC	1
B-D-GALP	1
B-D-GLCPNAC	1

PDB references: 38

1 - 5 of 38 PDB entries

PDB ID 6idb: Crystal structure of H7 hemagglutinin mutant H7-SVTQ ( A138S, P221T, L226Q) with 6'SLN

Description: Hemagglutinin

Source: Influenza A virus

Experimental method: X-RAY DIFFRACTION

Resolution: 2.502Å

Release date: 2019-11-27

Entry features 2 distinct glycan structures [3 instances].

PDB ID 6tzb: Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin in complex with 6'-SLNLN

Description: Hemagglutinin HA1, Hemagglutinin HA2

Source: Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

Experimental method: X-RAY DIFFRACTION

Resolution: 2.243Å

Release date: 2019-10-30

Entry features 7 distinct glycan structures [16 instances].

PDB ID 6cvb: CryoEM structure of human enterovirus D68 in complex with 6'-sialyl-N-acetyllactosamine

Description: viral protein 1, viral protein 3, viral protein 2, viral protein 4

Source: Enterovirus D68

Experimental method: ELECTRON MICROSCOPY

Release date: 2019-07-24

Entry features 1 distinct glycan structures [1 instances].

PDB ID 6nsb: Crystal structure of the IVR-165 (H3N2) influenza virus hemagglutinin in complex with 6'-SLNLN

Description: Hemagglutinin HA1, Hemagglutinin HA2

Source: Influenza A virus

Experimental method: X-RAY DIFFRACTION

Resolution: 1.75Å

Release date: 2019-04-24

Entry features 4 distinct glycan structures [9 instances].

PDB ID 6bkq: Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin E190D mutant in complex with 6'-SLN

Description: Hemagglutinin

Source: Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

Experimental method: X-RAY DIFFRACTION

Resolution: 2.25Å

Release date: 2018-02-28

Entry features 6 distinct glycan structures [14 instances].

Literature references: 14

1 - 5 of 14 literature references

Reference #21602

Hyun JY; Kim S; Lee CH; Lee HS; Shin I

Efficient Preparation and Bioactivity Evaluation of Glycan-Defined Glycoproteins.

Published 2021 in ACS Chem Biol, 16: 1930-1940

Reference contains 9 structures

Reference #21752

Nguyen T; Lee S; Yang YA; Ahn C; Sim JH; Kei TG; Barnard KN; Yu H; Millano SK; Chen X; Parrish CR; Song J

The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication.

Published 2020 in PLoS Pathog, 16: e1008336

Reference contains 5 structures

Reference #21286

Challenges and Pitfalls in Human Milk Oligosaccharide Analysis.

Published 2019 in Nutrients, 11:

Reference contains 50 structures

Reference #21050

Di Carluccio C; Crisman E; Manabe Manabey Chem Sci Osaka-U Ac J YMMCSOAJ; Forgione RE; Lacetera A; Amato J; Pagano B; Randazzo A; Zampella A; Lanzetta R; Koichi F; Molinaro A; Crocker PR; Martin-Santamaria S; Marchetti R; Silipo A

Characterisation of the dynamic interactions between complex N-glycans and human CD22.

Published 2019 in Chembiochem, :

Reference contains 6 structures

Reference #20424

Vasile F; Gubinelli F; Panigada M; Soprana E; Siccardi A; Potenza D

NMR interaction studies of Neu5Ac-α-(2,6)-Gal-β-(1-4)-GlcNAc with influenza-virus hemagglutinin expressed in transfected human cells.

Published 2018 in Glycobiology, 28: 42-49

Reference contains 3 structures

Further literature references from PDB entries: 19

1 - 5 of 19 literature references from PDB entries

Reference #20218

Tzarum N; de Vries RP; Peng W; Thompson AJ; Bouwman KM; McBride R; Yu W; Zhu X; Verheije MH; Paulson JC; Wilson IA

The 150-Loop Restricts the Host Specificity of Human H10N8 Influenza Virus.

Published 2017 in Cell Rep, 19: 235-245

Reference #20271

Wu NC; Xie J; Zheng T; Nycholat CM; Grande G; Paulson JC; Lerner RA; Wilson IA

Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.

Published 2017 in Cell Host Microbe, 21: 742-753.e8

Reference #20348

Ni F; Kondrashkina E; Wang Q

Determinant of receptor-preference switch in influenza hemagglutinin.

Published 2017 in Virology, 513: 98-107

Reference #19152

Zhang H; de Vries RP; Tzarum N; Zhu X; Yu W; McBride R; Paulson JC; Wilson IA

A human-infecting H10N8 influenza virus retains a strong preference for avian-type receptors.

Published 2015 in Cell Host Microbe, 17: 377-84

Reference #19389

Zhu X; Viswanathan K; Raman R; Yu W; Sasisekharan R; Wilson IA

Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants.

Published 2015 in Cell Rep, 13: 1683-91

NCBI Taxonomy ID	Scientific Name
9606	Homo sapiens

Consortium for Functional Glycomics (CFG):

Glyco-CD:

CD75s

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