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Glycosciences.DB structure entry #6656: 6'-Sialyllactosamin

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Format: CarbBank LINUCS GlycoCT_condensed GlycoCT_xml


 a-D-Neup5Ac-(2-6)-b-D-Galp-(1-4)-b-D-GlcpNAc


RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
5s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(4+1)3d
3:3o(6+2)4d
4:4d(5+1)5n


<?xml version="1.0" encoding="UTF-8"?>
 <sugar version="1.0">
 <residues>
 <basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dglc-HEX-1:5">
 <stemtype id="1" type="dglc" />
 </basetype>
 <substituent id="2" name="n-acetyl" />
 <basetype id="3" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
 <stemtype id="1" type="dgal" />
 </basetype>
 <basetype id="4" anomer="a" superclass="non" ringStart="2" ringEnd="6" name="a-dgro-dgal-NON-2:6|1:a|2:keto|3:d">
 <stemtype id="1" type="dgro" />
 <stemtype id="2" type="dgal" />
 <modification type="a" pos_one="1" />
 <modification type="keto" pos_one="2" />
 <modification type="d" pos_one="3" />
 </basetype>
 <substituent id="5" name="n-acetyl" />
 </residues>
 <linkages>
 <connection id="1" parent="1" child="2">
 <linkage id="1" parentType="d" childType="n">
 <parent pos="2" />
 <child pos="1" />
 </linkage>
 </connection>
 <connection id="2" parent="1" child="3">
 <linkage id="2" parentType="o" childType="d">
 <parent pos="4" />
 <child pos="1" />
 </linkage>
 </connection>
 <connection id="3" parent="3" child="4">
 <linkage id="3" parentType="o" childType="d">
 <parent pos="6" />
 <child pos="2" />
 </linkage>
 </connection>
 <connection id="4" parent="4" child="5">
 <linkage id="4" parentType="d" childType="n">
 <parent pos="5" />
 <child pos="1" />
 </linkage>
 </connection>
 </linkages>
 </sugar>

SNFG-style Graphics

3D Structure Model

download coordinates

Corresponding entries: 10

1 - 5 of 10 entries with matching glycan part

Structure entry #284:

a-D-Neup5Ac-(2-6)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-4)-Asn

NMR spectra

literature references

no GlycoMaps

Structure entry #524:

a-D-Neup5Ac-(2-6)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-Methyl

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #598:

a-D-Neup5Ac-(2-6)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-4)+ | Asn-(1-2)-Ser-(1-2)-Thr-(1-2)-Ile | <(allyloxy)carbonyl>-(1-2)-Phe-(1-2)+

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #599:

a-D-Neup5Ac-(2-6)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-4)+ | Asn-(1-2)-Gly-(1-2)-Gly | Gly-(1-2)-Gly-(1-2)+

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #14349:

a-D-Neup5Ac-(2-6)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-Pent-4-en-1-ol

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Lactosamine (Show) (Search Database)

6'-Sialyllactosamin
6SLN
6'-SLN
6'SLN

General Structure Data

Chemical Formula:	C₂₅H₄₂N₂O₁₉		#C	#H	#O	#N
Molec. Weight:	674		25	42	19	2
# Atoms:	88
# Residues:	3
# Heavy Atoms:	46

Superclasses:

Neu		Hex
NeuAc	1	Hex	1
		HexNAc	1

Residues:

Residue	Count
A-D-NEUP5AC	1
B-D-GALP	1
B-D-GLCPNAC	1

PDB references: 47

1 - 5 of 47 PDB entries

PDB ID 6y64: Structure of Sheep Polyomavirus VP1 in complex with 6'-Sialyllactosamine

Description: Capsid protein VP1

Source: Sheep polyomavirus 1

Experimental method: X-RAY DIFFRACTION

Resolution: 1.6Å

Release date: 2020-07-08

Entry features 3 distinct glycan structures [6 instances].

PDB ID 6p4r: Salmonella typhi PltB Homopentamer N29K Mutant with Neu5Ac-alpha-2-6-Gal-beta-1-4-GlcNAc glycans

Description: Putative pertussis-like toxin subunit

Source: Salmonella enterica subsp. enterica serovar Typhi str. CT18

Experimental method: X-RAY DIFFRACTION

Resolution: 1.87Å

Release date: 2020-03-25

Entry features 1 distinct glycan structures [5 instances].

PDB ID 6p4n: Salmonella typhi PltB Homopentamer with Neu5Ac-alpha-2-6-Gal-beta-1-4-GlcNAc Glycans

Description: Putative pertussis-like toxin subunit

Source: Salmonella enterica subsp. enterica serovar Typhi str. CT18

Experimental method: X-RAY DIFFRACTION

Resolution: 1.7Å

Release date: 2020-03-25

Entry features 1 distinct glycan structures [3 instances].

PDB ID 6idb: Crystal structure of H7 hemagglutinin mutant H7-SVTQ ( A138S, P221T, L226Q) with 6'SLN

Description: Hemagglutinin

Source: Influenza A virus

Experimental method: X-RAY DIFFRACTION

Resolution: 2.502Å

Release date: 2019-11-27

Entry features 2 distinct glycan structures [3 instances].

PDB ID 6tzb: Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin in complex with 6'-SLNLN

Description: Hemagglutinin HA1, Hemagglutinin HA2

Source: Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

Experimental method: X-RAY DIFFRACTION

Resolution: 2.243Å

Release date: 2019-10-30

Entry features 7 distinct glycan structures [16 instances].

Literature references: 17

1 - 5 of 17 literature references

Reference #22508

Munday RJ; Coradin T; Nimmo R; Lad Y; Hyde SC; Mitrophanos K; Gill DR

Sendai F/HN pseudotyped lentiviral vector transduces human ciliated and non-ciliated airway cells using α 2,3 sialylated receptors.

Published 2022 in Mol Ther Methods Clin Dev, 26: 239-252

Reference contains 7 structures

Reference #21907

Enterina JR; Sarkar S; Streith L; Jung J; Arlian BM; Meyer SJ; Takematsu H; Xiao C; Baldwin TA; Nitschke L; Shlomchick MJ; Paulson JC; Macauley MS

Coordinated changes in glycosylation regulate the germinal center through CD22.

Published 2022 in Cell Rep, 38: 110512

Reference contains 2 structures

Reference #21602

Hyun JY; Kim S; Lee CH; Lee HS; Shin I

Efficient Preparation and Bioactivity Evaluation of Glycan-Defined Glycoproteins.

Published 2021 in ACS Chem Biol, 16: 1930-1940

Reference contains 9 structures

Reference #22000

Sojitra M; Sarkar S; Maghera J; Rodrigues E; Carpenter EJ; Seth S; Ferrer Vinals D; Bennett NJ; Reddy R; Khalil A; Xue X; Bell MR; Zheng RB; Zhang P; Nycholat C; Bailey JJ; Ling CC; Lowary TL; Paulson JC; Macauley MS; Derda R

Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage.

Published 2021 in Nat Chem Biol, 17: 806-816

Reference contains 65 structures

Reference #21752

Nguyen T; Lee S; Yang YA; Ahn C; Sim JH; Kei TG; Barnard KN; Yu H; Millano SK; Chen X; Parrish CR; Song J

The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication.

Published 2020 in PLoS Pathog, 16: e1008336

Reference contains 5 structures

Further literature references from PDB entries: 21

1 - 5 of 21 literature references from PDB entries

Reference #22163

Lee S; Yang YA; Milano SK; Nguyen T; Ahn C; Sim JH; Thompson AJ; Hillpot EC; Yoo G; Paulson JC; Song J

Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence.

Published 2020 in Cell Host Microbe, 27: 937-949.e6

Reference #22238

Ströh LJ; Rustmeier NH; Blaum BS; Botsch J; Rößler P; Wedekink F; Lipkin WI; Mishra N; Stehle T

Structural Basis and Evolution of Glycan Receptor Specificities within the Polyomavirus Family.

Published 2020 in mBio, 11:

Reference #20218

Tzarum N; de Vries RP; Peng W; Thompson AJ; Bouwman KM; McBride R; Yu W; Zhu X; Verheije MH; Paulson JC; Wilson IA

The 150-Loop Restricts the Host Specificity of Human H10N8 Influenza Virus.

Published 2017 in Cell Rep, 19: 235-245

Reference #20271

Wu NC; Xie J; Zheng T; Nycholat CM; Grande G; Paulson JC; Lerner RA; Wilson IA

Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.

Published 2017 in Cell Host Microbe, 21: 742-753.e8

Reference #20348

Ni F; Kondrashkina E; Wang Q

Determinant of receptor-preference switch in influenza hemagglutinin.

Published 2017 in Virology, 513: 98-107

NCBI Taxonomy ID	Scientific Name
9606	Homo sapiens

Consortium for Functional Glycomics (CFG):

Glyco-CD:

CD75s

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