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Glycosciences.DB structure entry #50: Lewis X trisaccharide (beta-anomeric form)
b-D-Galp-(1-4)+
|
b-D-GlcpNAc
|
a-L-Fucp-(1-3)+
[][B-D-GLCPNAC]{[(3+1)][A-L-FUCP]{}[(4+1)][B-D-GALP]{}}
RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:a-lgal-HEX-1:5|6:d
4b:b-dgal-HEX-1:5
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(4+1)4d
<?xml version="1.0" encoding="UTF-8"?>
<sugar version="1.0">
<residues>
<basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dglc-HEX-1:5">
<stemtype id="1" type="dglc" />
</basetype>
<substituent id="2" name="n-acetyl" />
<basetype id="3" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-lgal-HEX-1:5|6:d">
<stemtype id="1" type="lgal" />
<modification type="d" pos_one="6" />
</basetype>
<basetype id="4" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
</residues>
<linkages>
<connection id="1" parent="1" child="2">
<linkage id="1" parentType="d" childType="n">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
<connection id="2" parent="1" child="3">
<linkage id="2" parentType="o" childType="d">
<parent pos="3" />
<child pos="1" />
</linkage>
</connection>
<connection id="3" parent="1" child="4">
<linkage id="3" parentType="o" childType="d">
<parent pos="4" />
<child pos="1" />
</linkage>
</connection>
</linkages>
</sugar>
3D Structure Model1 - 5 of 14 entries with matching glycan part
Structure entry #369:
b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-9)-9-hydroxy-Nonanoate-(1-1)-Methyl
|
a-L-Fucp-(1-3)+
 |
 13C: 1 |
 |
 : 3 |
 |
Taxons |
Structure entry #2036:
b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-1)-<linker-TMR>
|
a-L-Fucp-(1-3)+
|
 |
|
: 1 |
|
Taxons |
Structure entry #2174: Lewis X antigen, CD15
b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-3)-<rest of molecule>
|
a-L-Fucp-(1-3)+
|
|
|
: 3 |
|
Taxons: 3 |
Structure entry #2217:
b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-4)+
| |
b-D-Galp-(1-4)+ a-L-Fucp-(1-3)+ |
| Asn-(1-2)-Ala-(1-2)-Ser-(1-2)-Ala
b-D-GlcpNAc-(1-4)+ |
| | |
a-L-Fucp-(1-3)+ Asn-(1-2)-Gly-(1-2)+
|
Acetate-(1-2)+
|
|
|
: 1 |
|
Taxons |
Structure entry #4554:
b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-7)-benzyl
|
a-L-Fucp-(1-3)+
 |
|
|
: 1 |
|
Taxons |
- Lewis X (Show) (Search Database)
- LewisX
- LeX
- CD15
- Lewis-X
- Le-X
- Lewis X
| Chemical Formula: | C20H35N1O15 | #C | #H | #O | #N | |
| Molec. Weight: | 529 | 20 | 35 | 15 | 1 | |
| # Atoms: | 71 | |||||
| # Residues: | 3 | |||||
| # Heavy Atoms: | 36 | |||||
Superclasses:
|
Residues:
|
||||||||||||||||
PDB references: 71 - 5 of 7 PDB entries
PDB ID 6hjd:
Cholera toxin classical B-pentamer in complex with Lewis-x
Description: Cholera toxin B subunit
Source: Vibrio cholerae
Experimental method: X-RAY DIFFRACTION
Resolution: 1.54Å
Release date: 2019-08-14
Entry features 3 distinct glycan structures [9 instances].
PDB ID 6r35:
Structure of the LecB lectin from Pseudomonas aeruginosa strain PAO1 in complex with lewis x tetrasaccharide
Description: Fucose-binding lectin PA-IIL
Source: Pseudomonas aeruginosa PAO1
Experimental method: X-RAY DIFFRACTION
Resolution: 1.8Å
Release date: 2019-06-12
Entry features 1 distinct glycan structures [4 instances].
PDB ID 5o7v:
Crystal structure of the 5F-tryptophan RSL lectin in complex with Lewis x tetrasaccharide
Description: Putative fucose-binding lectin protein
Source: Ralstonia solanacearum
Experimental method: X-RAY DIFFRACTION
Resolution: 1.28Å
Release date: 2018-06-06
Entry features 3 distinct glycan structures [4 instances].
PDB ID 5o7u:
Crystal structure of the 7-Fluorotryptophan RSL lectin in complex with Lewis x tetrasaccharide
Description: Putative fucose-binding lectin protein
Source: Ralstonia solanacearum
Experimental method: X-RAY DIFFRACTION
Resolution: 1.15Å
Release date: 2018-06-06
Entry features 4 distinct glycan structures [4 instances].
PDB ID 5ajb:
X-ray structure of the RSL lectin in complex with Lewis X tetrasaccahride
Description: LECTIN
Source: RALSTONIA SOLANACEARUM
Experimental method: X-RAY DIFFRACTION
Resolution: 1.8Å
Release date: 2016-03-02
Entry features 3 distinct glycan structures [5 instances].
Conformational maps: 2
Map ID: 8431
Disaccharide Fragment: a-L-Fucp-(1-3)-b-D-GlcpNAc
Linkage Path: 3
Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns
Map ID: 8432
Disaccharide Fragment: b-D-Galp-(1-4)-b-D-GlcpNAc
Linkage Path: 4
Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns
Literature references: 1361 - 5 of 136 literature references
Reference #22029
Klarić TS; Lauc G
The dynamic brain N-glycome.
Published 2022 in Glycoconj J, 39: 443-471
Reference contains 18 structures
Reference #21964
Brockhausen I; Schutzbach J; Wang J; Fishwick B; Brockhausen J
Glycoconjugate journal special issue on: the glycobiology of Parkinson's disease.
Published 2022 in Glycoconj J, 39: 55-74
Reference contains 9 structures
Reference #21703
Ezeabikwa B; Mondal N; Antonopoulos A; Haslam SM; Matsumoto Y; Martin-Caraballo M; Lehoux S; Mandalasi M; Ishaque A; Heimburg-Molinaro J; Cummings RD; Nyame AK
Major differences in glycosylation and fucosyltransferase expression in low-grade versus high-grade bladder cancer cell lines.
Published 2021 in Glycobiology, 31: 1444-1463
Reference contains 15 structures
Reference #21648
Robakiewicz S; Bridot C; Serna S; Gimeno A; Echeverria B; Delgado S; de Ruyck J; Semwal S; Charro D; Dansercoer A; Verstraete K; Azkargorta M; van Noort K; Wilbers RHP; Savvides SN; Abrescia NGA; Arda A; Reichardt NC; Jiménez-Barbero J; Bouckaert J
Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins.
Published 2021 in Glycobiology, 31: 1005-1017
Reference contains 29 structures
Reference #21582
D'Addio M; Frey J; Otto VI
The manifold roles of sialic acid for the biological functions of endothelial glycoproteins.
Published 2020 in Glycobiology, 30: 490-499
Reference contains 4 structures
1 - 2 of 2 literature references from PDB entries
Reference #21145
Lepsik M; Sommer R; Kuhaudomlarp S; Lelimousin M; Paci E; Varrot A; Titz A; Imberty A
Induction of rare conformation of oligosaccharide by binding to calcium-dependent bacterial lectin: X-ray crystallography and modelling study.
Published 2019 in Eur J Med Chem, 177: 212-220
Reference #18827
Shanker S; Czako R; Sankaran B; Atmar RL; Estes MK; Prasad BV
Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses.
Published 2014 in J. Virol., 88: 6168-80
| NCBI Taxonomy ID | Scientific Name |
| 10141 | Cavia porcellus |
| 9534 | Cercopithecus aethiops |
| 10029 | Cricetulus griseus |
| 9031 | Gallus gallus |
| 9606 | Homo sapiens |
| 10090 | Mus musculus |
| 8638 | Naja |
| 9986 | Oryctolagus cuniculus |
| 10114 | Rattus |
| 6183 | Schistosoma mansoni |
Consortium for Functional Glycomics (CFG):
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